Exons of Leukemia Suppressor Genes: Creative Assembly Required

被引：2

作者：

Asnani, Mukta ^{[1
]}

Thomas-Tikhonenko, Andrei ^{[1
,2
]}

机构：

[1] Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

TRENDS IN CANCER | 2018年 / 4卷 / 12期

关键词：

D O I：

10.1016/j.trecan.2018.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alternative splicing (AS) has many important roles in the pathogenesis of leukemia. Recent papers suggest that one of its key aspects is exclusion of 30-terminal exons in favor of premature termination using intronic polyadenylation signals. This process generates leukemia suppressor isoforms with truncated C termini and acting in loss-of-function or dominantnegative manners.

引用

页码：796 / 798

页数：4

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