Highly enantioselective iridium-catalyzed hydrogenation of heteroaromatic compounds, quinolines

被引：484

作者：

Wang, WB ^{[1
]}

Lu, SM ^{[1
]}

Yang, PY ^{[1
]}

Han, XW ^{[1
]}

Zhou, YG ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 35期

关键词：

D O I：

10.1021/ja0353762

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The highly enantioselective hydrogenation of quinoline derivatives is developed using [Ir(COD)Cl]2/(R)-MeO-Biphep/I2 system, and this methodology has been applied to the asymmetric synthesis of three naturally occurring alkaloids angustureine, galipinine, and cuspareine. This method provided an efficient access to a variety of optically active tetrahydroquinolines with up to 96% ee. Copyright © 2003 American Chemical Society.

引用

页码：10536 / 10537

页数：2

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