Forecasting of Ventricular Tachyarrhythmia based on Multi-scale Entropy of Short-term Heart Rate Variability

The weighted integrated multi-scale entropy(WIMSE) is analyzed for the 135 about ten minutes RR interval series preceding the onset of ventricular tachycardia and ventricular fibrillation(called VT/VF series),and the change of WIMSE is discussed for the data samples of significant increase of heart rate (called SI_HR group) and no significant change of heart rate (called nSI_HR group) preceding the onset of VT/VF events. Results show that the WIMSE of VT/VF series has significantly reduction compared with normal sinus rhythm (scale:1-30, p<0.05),and the reduction of WIMSE is more significant for the VT/VF series of SI_HR group, the extracted complexity index (scale:1-10,p<10-6). Therefore the WIMSE may be an effective nonlinear predictive parameters for forecasting VT/VF events.