The creolophins:: A family of linear triquinanes from Creolophus cirrhatus (Basidiomycete)

被引：8

作者：

Opatz, Till

Kolshorn, Heinz

Birnbacher, Judith

Schueffler, Anja

Deininger, Friederike

Anke, Timm

机构：

[1] Univ Hamburg, Inst Organ Chem, D-2000 Hamburg, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[3] Inst Biotechnol & Wirkstoff Forsch, D-67663 Kaiserslautern, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 33期

关键词：

terpenoids; natural products; structure elucidation; NMR spectroscopy;

D O I：

10.1002/ejoc.200700555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Complicatic acid and five novel linear triquinanes were isolated from mycelial cultures of Creolophus cirrhatus. The creolophins A, C, D, and E represent a novel type of highly oxidized triquinane sesquiterpenoids. Whereas those compounds with a secondary alcohol moiety in ring A are stable, the exomethylene ketone creolophin E (5) partly dimerized during workup to form the decacyclic 1,4-dioxepin-6-one neocreolophin (6). Compounds 5 and 6 display cytotoxic activities against several tumor cell lines.

引用

页码：5546 / 5550

页数：5

共 7 条

[1] Bioactive sesquiterpenes produced by fungi: are they useful for humans as well? [J].