Changes of intestinal microflora diversity in diarrhea model of KM mice and effects of Psidium guajava']java L. as the treatment agent for diarrhea

被引：27
|
作者：
Lu, Junjia [3 ]
Mao, Dechang [2 ]
Li, Xiang [7 ]
Ma, Yunqiang [6 ]
Luan, Yunqi [4 ]
Cao, Yong [5 ]
Luan, Yunpeng [1 ,2 ]
机构：
[1] Southwest Forestry Univ, Key Lab Forest Resources Conservat & Utilizat Sou, Minist Educ, 300 Bailong Temple, Kunming 652400, Yunnan, Peoples R China
[2] Southwest Forestry Univ, Dept Life Technol Teaching & Res, Sch Life Sci, Kunming, Yunnan, Peoples R China
[3] Southwest Univ, Coll Biodivers Conservat & Utilisat, Georgetown, TX USA
[4] Lomonosov Moscow State Univ, Moscow, Russia
[5] Southwest Forestry Univ, Dept Life Technol Teaching & Res, Coll Life Sci, Kunming, Yunnan, Peoples R China
[6] Chinese Acad Forest, Res Inst Resources & Insects, Chinese Acad Forestry, Kunming 650224, Yunnan, Peoples R China
[7] Huazhong Univ Sci & Technol, Dept Immunol, Sch Basic Med, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
来源：
JOURNAL OF INFECTION AND PUBLIC HEALTH | 2020年 / 13卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Psidium gua[!text type='java']java[!/text] L; Diarrhea; Intestinal microflora; ERIC-PCR; 16S-rDNA; Bacteroidetes; Deferribacteraceae; DNA;
D O I：
10.1016/j.jiph.2019.04.015
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objectives: This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. Methods: Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose stools rates, diarrhea rates, diarrhea index and motor functions of intestine. Results: Our results showed that all three kinds of extracts from Psidium guajava L. had inhibitory effects on Folium Sennae induced diarrhea model. The proportion of Bacteroidetes is lower in Group DF (diarrhea model group) compared with Group B (blank group), while abundance of Deferribacteraceae was found in Group DF. The proportion of Deferribacteraceae lowered in Group DTF (diarrhea treatment group) treated with extracts from Psidium guajava L. Conclusions: However, mechanisms underlying the therapeutic effect of Psidium guajava L. and the changes in intestinal microflora still await further exploration. (C) 2019 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences.
引用
收藏
页码：16 / 26
页数：11
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