Facile one-pot multicomponent synthesis of 1H-pyrazolo[3,4-b]quinolines using L-proline as a catalyst

被引：7

作者：

Hegde, Hemant ^{[1
]}

Shetty, Nitinkumar S. ^{[1
]}

机构：

[1] Manipal Inst Technol, Dept Chem, Manipal 576104, Karnataka, India

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2017年 / 53卷 / 08期

关键词：

L-proline; 1H-pyrazolo[3,4-b]quinolines; multicomponent reaction; one-pot synthesis; organocatalyst; ORGANIC-SYNTHESIS; ANTIBACTERIAL ACTIVITY; BIOLOGICAL-ACTIVITIES; BIGINELLI REACTION; DERIVATIVES; CHEMISTRY; PYRAZOLE; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; INHIBITORS; DESIGN;

D O I：

10.1007/s10593-017-2152-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol for the synthesis of a new series of 1H-pyrazolo[3,4-b]quinolines has been described. The target compounds have been synthesized by one-pot multicomponent reaction of aniline, aromatic aldehydes, and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one using L-proline as an organocatalyst. Structural diversity and high yields of products, broad scope of aromatic aldehydes, simple operation, and short reaction times have been demonstrated as the advantages of the developed synthetic approach.

引用

页码：883 / 886

页数：4

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