Absence of Neuroinvasive Disease in a Liver Transplant Recipient Who Acquired West Nile Virus (WNV) Infection from the Organ Donor and Who Received WNV Antibodies Prophylactically

被引：37

作者：

Morelli, Maria Cristina ^{[2
]}

Sambri, Vittorio ^{[1
]}

Grazi, Gian Luca ^{[2
]}

Gaibani, Paolo ^{[1
]}

Pierro, Anna ^{[1
]}

Cescon, Matteo ^{[2
]}

Ercolani, Giorgio ^{[2
]}

Cavrini, Francesca ^{[1
]}

Rossini, Giada ^{[1
]}

Capobianchi, Maria Rosaria ^{[4
]}

Di Caro, Antonino ^{[4
]}

Menzo, Stefano ^{[4
]}

Pagliaro, Pasquale Paolo ^{[3
]}

Ghinelli, Florio ^{[5
]}

Lazzarotto, Tiziana ^{[1
]}

Landini, Maria Paola ^{[1
]}

Pinna, Antonio Daniele ^{[2
]}

机构：

[1] S Orsola Univ Hosp, Clin Microbiol Unit, Bologna, Italy

[2] S Orsola Univ Hosp, Liver & Multiorgan Transplant Unit, Bologna, Italy

[3] S Orsola Univ Hosp, Blood Bank, Bologna, Italy

[4] Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[5] St Anna Hosp, Infect Dis Unit, Ferrara, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 04期

关键词：

D O I：

10.1086/655146

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the first case of West Nile virus infection in Europe with transmission from donor to recipient following liver transplantation. The infection was detected in the recipient 3 days after transplantation, during the asymptomatic phase. We also report an innovative prophylactic strategy based on infusion of West Nile virus hyperimmune plasma and gamma globulins that could be effective in preventing the appearance of a neuroinvasive disease.

引用

页码：E34 / E37

页数：4

共 18 条

[1] Human immunoglobulin as a treatment for West Nile virus infection [J].

Agrawal, AG ;

Petersen, LR .

JOURNAL OF INFECTIOUS DISEASES, 2003, 188 (01) :1-4

[2]

[Anonymous], EURO SURVEILL

[3]

[Anonymous], EURO SURVEILL

[4] Emerging Viruses in Transplantation: There Is More to Infection After Transplant Than CMV and EBV [J].

Fischer, Staci A. .

TRANSPLANTATION, 2008, 86 (10) :1327-1339

[5] West Nile Virus: Pathogenesis and therapeutic options [J].

Gea-Banacloche, J ;

Johnson, RT ;

Bagic, A ;

Butman, JA ;

Murray, PR ;

Agrawal, AG .

ANNALS OF INTERNAL MEDICINE, 2004, 140 (07) :545-553

[6] Pathogenic flaviviruses [J].

Gould, E. A. ;

Solomon, T. .

LANCET, 2008, 371 (9611) :500-509

[7] West Nile virus in Italy: a further threat to blood safety, a further challenge to the blood system [J].

Grazzini, Giuliano ;

Liumbruno, Giancarlo Maria ;

Pupella, Simonetta ;

Silvestri, Anna Rita ;

Randi, Vanda ;

Pascarelli, Nadia ;

Zucchelli, Paolo ;

Di Caro, Antonino ;

Spataro, Nadir ;

D'Angelo, Erika ;

Sambri, Vittorio .

BLOOD TRANSFUSION, 2008, 6 (04) :235-237

[8] The continuing spread of West Nile virus in the Western Hemisphere [J].

Gubler, Duane J. .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (08) :1039-1046

[9] West Nile Virus Infections [J].

Gyure, Kymberly A. .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2009, 68 (10) :1053-1060

[10] The role for intravenous immunoglobulin in the treatment of West Nile virus encephalitis [J].

Haley, M ;

Retter, AS ;

Fowler, D ;

Gea-Banacloche, J ;

O'Grady, NP .

CLINICAL INFECTIOUS DISEASES, 2003, 37 (06) :E88-E90

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