COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy

被引：64

作者：

Albertini, R. ^{[1
]}

Aimbire, F. ^{[1
]}

Villaverde, A. B. ^{[1
]}

Silva, J. A., Jr. ^{[1
]}

Costa, M. S. ^{[1
]}

机构：

[1] UNIVAP, IP&D, BR-12244 Sao Jose Dos Campos, Brazil

来源：

INFLAMMATION RESEARCH | 2007年 / 56卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

inflammation; COX-2; LLLT;

D O I：

10.1007/s00011-007-6211-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective and design: Low level laser therapy (LLLT) has been presented as a novel therapy to treat inflammation. Herein we studied the effect of LLLT on the COX-2 mRNA expression in subplantar tissue taken from rats treated with carrageenan. Material: The groups consisted of 32 rats: A (1) (Saline), A (2) (Carrageenan), A (3) (Carrageenan + laser 660 nm) and A (4) (Carrageenan + laser 684 nm). Treatment: A(3) and A(4) were irradiated in the first hour after carrageenan. Methods: The edema was measured by a plethysmometer and COX-2 mRNA was by RT-PCR. Statistical were evaluated by ANOVA and Tukey-Kramer Test. Results: Carrageenan increased both edema (A(1)= 0.6 +/- 0.04 vs. A(2)= 2.24 +/- 0.08) and COX-2 mRNA (A(1)= 1.1 +/- 0.26 vs. A(2)= 3.52 +/- 0.69). Irradiation reduced the edema (A(3)= 0.84 +/- 0.09; A(4)= 1.31 +/- 0.05) and the COX-2 mRNA (A(3)= 2.16 +/- 0.28; A(4)= 1.86 +/- 0.20). Conclusion: LLLT reduce the expression of COX-2 mRNA.

引用

页码：228 / 229

页数：2

共 7 条

[1] Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema [J].