Synthesis and characterization of HPMA copolymer-5-FU conjugates

被引：11
|
作者：
Yuan, Fang [1 ]
Chen, Fu [1 ]
Xiang, Qing Yu [1 ]
Qin, Xuan [1 ]
Zhang, Zhi Rong [1 ]
Huang, Yuan [1 ]
机构：
[1] Sichuan Univ, W China Sch Pharm, Minist Educ, Key Lab Drug Targeting, Chengdu 610041, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 02期
基金：
中国国家自然科学基金;
关键词：
HPMA copolymer; 5-fluorouracil; conjugates; characterization; stability;
D O I：
10.1016/j.cclet.2007.10.035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-(2-Hydroxypropyl) methacrylamide copolymer-5-fluorouracil (PHPMA-FU) conjugates were synthesized by a novel and simplified synthetic route, and characterized by UV, FTIR and HPLC analyses. The conjugated content of 5-fluorouracil (5-FU) was 3.41 +/- 0.07 wt%. The stabilities of PHPMA-FU conjugates under different conditions were studied. The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU. (c) 2007 Yuan Huang. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：137 / 140
页数：4
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