SARS CoV-2 aggravates cellular metabolism mediated complications inCOVID-19 infection

被引：32

作者：

Singh, Yogendra ^{[1
]}

Gupta, Gaurav ^{[2
]}

Kazmi, Imran ^{[3
]}

Al-Abbasi, Fahad A. ^{[3
]}

Negi, Poonam ^{[4
]}

Chellappan, Dinesh Kumar ^{[5
]}

Dua, Kamal ^{[6
,7
,8
,9
]}

机构：

[1] Mahatma Gandhi Coll Pharmaceut Sci, Jaipur, Rajasthan, India

[2] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur, Rajasthan, India

[3] King Abdulaziz Univ, Dept Biochem, Fac Sci, Jeddah, Saudi Arabia

[4] Shoolini Univ, Sch Pharmaceut Sci, Solan, Himachal Prades, India

[5] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia

[6] Univ Technol Sydney UTS, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW, Australia

[7] Univ Newcastle UoN, Hunter Med Res Inst HMRI, Prior Res Ctr Hlth Lungs, Callaghan, NSW, Australia

[8] Univ Newcastle UoN, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia

[9] Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia

来源：

DERMATOLOGIC THERAPY | 2020年 / 33卷 / 06期

关键词：

COVID-19; SARS-CoV-2;

D O I：

10.1111/dth.13871

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

引用

页数：3

共 10 条

[1] [Anonymous], 2020, N ENGL J MED
[2] In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation
Bouvet, Mickael
Debarnot, Claire
Imbert, Isabelle
Selisko, Barbara
Snijder, Eric J.
Canard, Bruno
Decroly, Etienne
[J]. PLOS PATHOGENS, 2010, 6 (04) : 1 - 13
[3] Butz LW, 1932, J BIOL CHEM, V99, P135
[4] Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System
De Felice, Fernanda G.
Tovar-Moll, Fernanda
Moll, Jorge
Munoz, Douglas P.
Ferreira, Sergio T.
[J]. TRENDS IN NEUROSCIENCES, 2020, 43 (06) : 355 - 357
[5] Emerging dermatological symptoms in coronavirus pandemic
Gupta, Gaurav
Singh, Yogendra
Chellappan, Dinesh
Dua, Kamal
[J]. JOURNAL OF COSMETIC DERMATOLOGY, 2020, 19 (09) : 2447 - 2448
[6] Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
Li, Tuoyi
Yu, Bing
Liu, Zhixin
Li, Jingyuan
Ma, Mingliang
Wang, Yingbao
Zhu, Mingjiang
Yin, Huiyong
Wang, Xiaofeng
Fu, Yi
Yu, Fang
Wang, Xian
Fang, Xiaohong
Sun, Jinpeng
Kong, Wei
[J]. NATURE COMMUNICATIONS, 2018, 9
[7] IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice
Page, Angustias
Bravo, Ana
Suarez-Cabrera, Cristian
Sanchez-Baltasar, Raquel
Oteo, Marta
Angel Morcillo, Miguel
Llanos Casanova, M.
Segovia, Jose C.
Navarro, Manuel
Ramirez, Angel
[J]. INTERNATIONAL JOURNAL OF ORAL SCIENCE, 2020, 12 (01)
[8] RAASblockers in hypertension posing a higher risk toward theCOVID-19
Singh, Yogendra
Gupta, Gaurav
Satija, Saurabh
Negi, Poonam
Chellappan, Dinesh K.
Dua, Kamal
[J]. DERMATOLOGIC THERAPY, 2020, 33 (04)
[9] Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China
Wang, Dawei
Hu, Bo
Hu, Chang
Zhu, Fangfang
Liu, Xing
Zhang, Jing
Wang, Binbin
Xiang, Hui
Cheng, Zhenshun
Xiong, Yong
Zhao, Yan
Li, Yirong
Wang, Xinghuan
Peng, Zhiyong
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (11): : 1061 - 1069
[10] Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes
Zhang, Q
Zeng, XK
Guo, JX
Wang, M
[J]. CARDIOVASCULAR RESEARCH, 2002, 53 (04) : 1035 - 1042

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