SARS CoV-2 aggravates cellular metabolism mediated complications inCOVID-19 infection

被引：32

作者：

Singh, Yogendra ^{[1
]}

Gupta, Gaurav ^{[2
]}

Kazmi, Imran ^{[3
]}

Al-Abbasi, Fahad A. ^{[3
]}

Negi, Poonam ^{[4
]}

Chellappan, Dinesh Kumar ^{[5
]}

Dua, Kamal ^{[6
,7
,8
,9
]}

机构：

[1] Mahatma Gandhi Coll Pharmaceut Sci, Jaipur, Rajasthan, India

[2] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur, Rajasthan, India

[3] King Abdulaziz Univ, Dept Biochem, Fac Sci, Jeddah, Saudi Arabia

[4] Shoolini Univ, Sch Pharmaceut Sci, Solan, Himachal Prades, India

[5] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia

[6] Univ Technol Sydney UTS, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW, Australia

[7] Univ Newcastle UoN, Hunter Med Res Inst HMRI, Prior Res Ctr Hlth Lungs, Callaghan, NSW, Australia

[8] Univ Newcastle UoN, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia

[9] Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia

来源：

DERMATOLOGIC THERAPY | 2020年 / 33卷 / 06期

关键词：

COVID-19; SARS-CoV-2;

D O I：

10.1111/dth.13871

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

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