C-I-Selective Cross-Coupling Enabled by a Cationic Palladium Trimer

被引：52

作者：

Diehl, Claudia J. ^{[1
]}

Scattolin, Thomas ^{[1
]}

Englert, Ulli ^{[1
]}

Schoenebeck, Franziska ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 01期

关键词：

C-C bond formation; chemoselectivity; cross-coupling; density functional calculations; palladium trimers; INTERNAL ALKYNES; ARYL IODIDES; PD(I) DIMER; SEMI-REDUCTION; CATALYST; REACTIVITY; PD; COMPLEXES; BROMIDES; CLUSTERS;

D O I：

10.1002/anie.201811380

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air-stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C-I over C-Br bonds in C-C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd-0 and Pd-I-Pd-I catalysts fail to deliver. Experimental and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible.

引用

页码：211 / 215

页数：5