The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells

被引：15
作者：
Babaei, Ghader [1 ]
Vostakolaei, Mehdi Asghari [2 ]
Bazl, Masoumeh Rajabi [3 ]
Aziz, Shiva Gholizadeh-Ghaleh [1 ]
Gholipour, Elham [4 ]
Nejati-Koshki, Kazem [5 ]
机构：
[1] Urmia Univ Med Sci, Fac Med, Dept Clin Biochem, Orumiyeh, Iran
[2] Ardabil Univ Med Sci, Digest Dis Res Ctr, Ardebil, Iran
[3] Shahid Beheshti Univ Med Sci SBUMS, Fac Med, Dept Clin Biochem, Tehran, Iran
[4] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Tabriz, Iran
[5] Ardabil Univ Med Sci, Pharmaceut Sci Res Ctr, Ardebil, Iran
来源：
LIFE SCIENCES | 2022年 / 310卷
关键词：
Exosomes; Metastasis; EMT; Cancer stem cells; EPITHELIAL-MESENCHYMAL TRANSITION; SIGNALING PATHWAY; MEDIATED EMT; DELIVERY; INVASION; PROLIFERATION; BIOGENESIS; EXPRESSION; SECRETION; PHENOTYPE;
D O I：
10.1016/j.lfs.2022.121103
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Exosomes are cell-derived small membrane-encapsulated vesicles that transfer biomolecules to surrounding cells. Exosomes play fundamental roles in cell-cell communications. They can also aggravate cancer progression and metastasis. Metastasis is a complicated and multi-serial process that is regulated by various mechanisms. Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are important participants in cancer metastasis. Recent studies demonstrate that exosomes are associated with metastasis by modulating the EMT and the function of CSCs. Accumulating evidence shows that exosomes are implicated in regulating tumor cell metastasis by modulating signaling pathways involved in EMT and CSCs. This review aims to discuss the effect of exosomes on signaling pathways associated with EMT and CSCs, as well as possible therapeutic strategies of exosomes in cancer metastasis.
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页数：12
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