Porous wollastonite hydroxyapatite bioceramics from a preceramic polymer and micro- or nano-sized fillers

被引：32

作者：

Bernardo, Enrico ^{[1
]}

Colombo, Paolo ^{[1
,5
]}

Cacciotti, Ilaria ^{[2
]}

Bianco, Alessandra ^{[2
]}

Bedini, Rossella ^{[3
]}

Pecci, Raffaella ^{[3
]}

Pardun, Karoline ^{[4
]}

Treccani, Laura ^{[4
]}

Rezwan, Kurosch ^{[4
]}

机构：

[1] Univ Padua, Dipartimento Ingn Meccan, I-35100 Padua, Italy

[2] Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, INSTM UdR Roma Tor Vergata, Rome, Italy

[3] Italian Natl Inst Hlth, Technol & Hlth Dept, Rome, Italy

[4] Univ Bremen, Adv Ceram Grp, Fac Prod Engn, Bremen, Germany

[5] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

来源：

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY | 2012年 / 32卷 / 02期

关键词：

Precursors; Nanocomposites; Apatite; Silicate; Biomedical applications; ALUMINA NANOPARTICLES; THERMAL-STABILITY; MULLITE SYNTHESIS; CERAMICS; GLASS; SCAFFOLDS; PROLIFERATION; FABRICATION;

D O I：

10.1016/j.jeurceramsoc.2011.08.010

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Wollastonite hydroxyapatite ceramics have been successfully prepared by a novel method, corresponding to the thermal treatment in air of a silicone embedding micro- and nano-sized fillers. CaCO3 nano-sized particles, providing CaO upon decomposition, acted as "active" filler, whereas different commercially available or synthesised hydroxyapatite particles were used as "passive" tiller. The homogeneous distribution of CaO, at a quasi-molecular level, favoured the reaction with silica derived from the polymer, at only 900 degrees C, preventing extensive decomposition of hydroxyapatite. Open-celled porous ceramics suitable for scaffolds for bone tissue engineering applications were easily prepared from filler-containing silicone resin mixed with sacrificial PMMA microbeads as templates. The pore size (in the range of 80-400 mu m) and the open porosity percentage (40-50%) were evaluated by means of micro-computerized tomographic analysis. A preliminary assessment of the biocompatibility and cell activity of the produced ceramics was performed successfully by in vitro tests using human osteoblast cells. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：399 / 408

页数：10

共 32 条

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