Porous wollastonite hydroxyapatite bioceramics from a preceramic polymer and micro- or nano-sized fillers

Wollastonite hydroxyapatite ceramics have been successfully prepared by a novel method, corresponding to the thermal treatment in air of a silicone embedding micro- and nano-sized fillers. CaCO3 nano-sized particles, providing CaO upon decomposition, acted as "active" filler, whereas different commercially available or synthesised hydroxyapatite particles were used as "passive" tiller. The homogeneous distribution of CaO, at a quasi-molecular level, favoured the reaction with silica derived from the polymer, at only 900 degrees C, preventing extensive decomposition of hydroxyapatite. Open-celled porous ceramics suitable for scaffolds for bone tissue engineering applications were easily prepared from filler-containing silicone resin mixed with sacrificial PMMA microbeads as templates. The pore size (in the range of 80-400 mu m) and the open porosity percentage (40-50%) were evaluated by means of micro-computerized tomographic analysis. A preliminary assessment of the biocompatibility and cell activity of the produced ceramics was performed successfully by in vitro tests using human osteoblast cells. (C) 2011 Elsevier Ltd. All rights reserved.