Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

被引：46
作者：
Wang, Lisheng [1 ]
You, Yejun [1 ]
Wang, Songqing [1 ]
Liu, Xu [1 ]
Liu, Buming [2 ]
Wang, Jinni [3 ]
Lin, Xiao [2 ]
Chen, Mingsheng [2 ]
Liang, Gang [3 ]
Yang, Hua [1 ]
机构：
[1] Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Peoples R China
[2] Guangxi Inst Tradit Med & Pharmaceut Sci, Guangxi Key Lab Tradit Chinese Med Qual Stand, Nanning 530022, Peoples R China
[3] Guangxi Med Univ, Coll Pharm, Nanning 530022, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 12期
关键词：
Matrine derivative; Synthesis; Anti-tumor activity; ASYMMETRIC-SYNTHESIS; ACID;
D O I：
10.1016/j.bmcl.2012.04.069
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4100 / 4102
页数：3
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