A dual CCR2/CCR5 chemokine antagonist, BMS-813160?

被引：16

作者：

Norman, Peter ^{[1
]}

机构：

[1] Norman Consulting, Burnham SL1 8JW, Bucks, England

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2011年 / 21卷 / 12期

关键词：

atherosclerosis; BMS-813160; cardiovascular disease; CCR2; antagonist; CCR5; CCR2; PHARMACOKINETICS; RECEPTORS;

D O I：

10.1517/13543776.2011.622750

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This application claims the dual CCR2/CCR5 antagonist (S)-1-[(1S, 2R, 4R)-4-isopropyl(methyl)amino)-2-propylcyclohexyl]-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-2-one, crystalline form N-1, a process for its preparation and therapeutic uses of it. The compound is shown to be a potent, well-absorbed, drug with a good duration of action. It shows better properties than similar compounds previously claimed by Bristol-Myers Squibb and appears to be a clinical development candidate.

引用

页码：1919 / 1924

页数：6

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