Plasma biomarker profiling in the detection of growth promoter use in calves

被引：31

作者：

Mooney, M. H. ^{[1
]}

Situ, C. ^{[1
]}

Cacciatore, G. ^{[2
]}

Hutchinson, T. ^{[3
]}

Elliott, C. ^{[1
]}

Bergwerff, A. A. ^{[2
]}

机构：

[1] Queens Univ Belfast, Sch Biol Sci, Inst Agri Food & Land Use, Belfast BT9 5AG, Antrim, North Ireland

[2] Univ Utrecht, IRAS, Vet Publ Hlth Div, Utrecht, Netherlands

[3] Agri Food Biosci Inst, Belfast, Antrim, North Ireland

来源：

BIOMARKERS | 2008年 / 13卷 / 03期

关键词：

growth promoters; veal calves; plasma biomarkers; SHBG; PIIINP; urea;

D O I：

10.1080/13547500701838593

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The detection of illicit growth promoter use during meat production within the European Union is reliant on residue testing which is a limiting factor on the number of animals which can be tested and consequently compromises the efficacy of testing procedures. The present study examined a novel detection strategy based on the profiling of plasma component concentrations in response to growth promoter administrations. Calves subjected to nortestosterone decanoate, 17 beta-oestradiol benzoate and dexamethasone were found to have altered urea, aminoterminal propeptide of type III procollagen and sex hormone binding globulin profiles in response to treatments. These findings demonstrate the potential of using the identification of perturbed profiles within a panel of biomarkers which cover a spectrum of biological activity to reveal growth promoter abuse.

引用

页码：246 / 256

页数：11

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