Since ancient times, numerous health beneficial effects have been attributed to chocolate, closing up its consumption to a therapeutic use. The present study reviews some relevant studies about chocolate (and its bioactive compounds) on some cardiovascular risk factors and stresses the need of future studies. The consumption of cocoa/chocolate (i) increases plasma antioxidant capacity, (ii) diminishes platelet function and inflammation, and (iii) decreases diastolic and systolic arterial pressures. Data currently available indicate that daily consumption of cocoa-rich chocolate (rich in polyphenols) may at least partially lower cardiovascular disease risk. Further studies are required in order to establish the bioavailability and mechanisms of action of bioactive compounds in chocolate. The study of the interaction of chocolate and its components with candidate genes will also supply necessary information regarding the individuals best suited to benefit from a potential cardiovascular disease treatment with chocolate.
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
di Giuseppe, Romina
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Di Castelnuovo, Augusto
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Di Castelnuovo, Augusto
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Centritto, Floriana
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Centritto, Floriana
;
Zito, Francesco
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Zito, Francesco
;
De Curtis, Amalia
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
De Curtis, Amalia
;
Costanzo, Simona
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Costanzo, Simona
;
Vohnout, Branislav
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Vohnout, Branislav
;
Sieri, Sabina
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Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Sieri, Sabina
;
Krogh, Vittorio
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Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Krogh, Vittorio
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Donati, Maria Benedetta
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Donati, Maria Benedetta
;
de Gaetano, Giovanni
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
de Gaetano, Giovanni
;
Iacoviello, Licia
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
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Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Faridi, Zubaida
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Njike, Valentine Yanchou
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Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Njike, Valentine Yanchou
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Dutta, Suparna
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Griffin Hosp, Prevent Res Ctr, Derby, CT 06418 USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Dutta, Suparna
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Ali, Ather
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Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Ali, Ather
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Katz, David L.
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Griffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Yale Univ, Sch Med, New Haven, CT USA
Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
机构:
Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
di Giuseppe, Romina
;
Di Castelnuovo, Augusto
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Di Castelnuovo, Augusto
;
Centritto, Floriana
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Centritto, Floriana
;
Zito, Francesco
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Zito, Francesco
;
De Curtis, Amalia
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
De Curtis, Amalia
;
Costanzo, Simona
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Costanzo, Simona
;
Vohnout, Branislav
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Vohnout, Branislav
;
Sieri, Sabina
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Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Sieri, Sabina
;
Krogh, Vittorio
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Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Krogh, Vittorio
;
Donati, Maria Benedetta
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
Donati, Maria Benedetta
;
de Gaetano, Giovanni
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
de Gaetano, Giovanni
;
Iacoviello, Licia
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Catholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, ItalyCatholic Univ, John Paul Ctr High Technol Res Care & Educ Biomed, Lab Genet & Environm Epidemiol, Res Labs, I-86100 Campobasso, Italy
机构:
Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Faridi, Zubaida
;
Njike, Valentine Yanchou
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Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Njike, Valentine Yanchou
;
Dutta, Suparna
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Griffin Hosp, Prevent Res Ctr, Derby, CT 06418 USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Dutta, Suparna
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Ali, Ather
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Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Ali, Ather
;
Katz, David L.
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Griffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA
Yale Univ, Sch Med, New Haven, CT USA
Yale Prevent Res Ctr, Derby, CT USAGriffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA