Complementation tagging of cooperating oncogenes in knockout mice

被引：37

作者：

Allen, JD

Berns, A

机构：

[1] Division of Molecular Genetics, Netherlands Cancer Institute, 1066 CX Amsterdam

来源：

SEMINARS IN CANCER BIOLOGY | 1996年 / 7卷 / 05期

关键词：

complementation; gene targetting; pim-1; proviral tagging; suppressor mutation;

D O I：

10.1006/scbi.1996.0038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene disruption and overexpression in mice can be combined with proviral tagging to investigate the biochemical pathways in which oncogenes act. The phenomenon of oncogene collaboration permits a focussed genetic approach analogous to the strategies employed in suppressor screens in invertebrates and yeast. We illustrate here its application to investigating the action of the pim kinases in tumorigenesis. However, it should be possible to utilize this strategy for dissecting a much wider range of biochemical pathways in mammalian systems.

引用

页码：299 / 306

页数：8

共 37 条

[1]

ADAMS JM, 1992, CANCER SURV, V15, P119

[2] ONCOGENE COOPERATION IN LYMPHOCYTE-TRANSFORMATION - MALIGNANT CONVERSION OF E-MU-MYC TRANSGENIC PRE-B CELLS-INVITRO IS ENHANCED BY V-H-RAS OR V-RAF BUT NOT V-ABL [J].