sp3 C-H Bond Activation with Ruthenium(II) Catalysts and C(3)-Alkylation of Cyclic Amines

被引：159
|
作者：
Sundararaju, Basker [1 ]
Achard, Mathieu [1 ]
Sharma, Gangavaram V. M. [2 ]
Bruneau, Christian [1 ]
机构：
[1] Univ Rennes, CNRS UMR6226, F-35042 Rennes, France
[2] Indian Inst Chem Technol CSIR, Discovery Lab, Div Organ Chem 3, Hyderabad 500007, Andhra Pradesh, India
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 27期
关键词：
HYDROGEN-TRANSFER REACTIONS; TERTIARY-AMINES; OXIDATIVE CYANATION; BORROWING HYDROGEN; SODIUM-CYANIDE; NITROGEN ATOM; DEHYDROGENATION; COMPLEXES; ADJACENT; ALKENES;
D O I：
10.1021/ja203875d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.
引用
收藏
页码：10340 / 10343
页数：4
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