The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

被引：26
作者：
Bhattacharya, Indranil [1 ]
Ghayor, Chafik [1 ]
Weber, Franz E. [1 ]
机构：
[1] Univ Zurich, Ctr Dent Med, Oral Biotechnol & Bioengn, Craniomaxillofacial & Oral Surg, Zurich, Switzerland
来源：
TRANSFUSION MEDICINE AND HEMOTHERAPY | 2016年 / 43卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
Bone regeneration; Adipose tissue-derived stem cells; Epigenetics; BETA-TRICALCIUM PHOSPHATE; ENDOTHELIAL GROWTH-FACTOR; STEM-CELLS; MORPHOGENETIC PROTEIN-2; OSTEOGENIC DIFFERENTIATION; PERFUSION BIOREACTOR; MARROW ASPIRATE; SCAFFOLD; DELIVERY; DEFECTS;
D O I：
10.1159/000447494
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2500 years ago, Hippocrates realized that bone can heal without scaring. The natural healing potential of bone is, however, restricted to small defects. Extended bone defects caused by trauma or during tumor resections still pose a huge problem in orthopedics and cranio-maxillo-facial surgery. Bone tissue engineering strategies using stem cells, growth factors, and scaffolds could overcome the problems with the treatment of extended bone defects. In this review, we give a short overview on bone tissue engineering with emphasis on the use of adipose tissue-derived stem cells and small molecules. (C) 2016 S. Karger GmbH, Freiburg
引用
收藏
页码：336 / 343
页数：8
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