Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory

被引：53

作者：

Ashworth, Jennifer C. ^{[1
]}

Mehr, Marco ^{[2
]}

Buxton, Paul G. ^{[2
]}

Best, Serena M. ^{[1
]}

Cameron, Ruth E. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB3 0FS, England

[2] Geistlich Pharma AG, Core Technol, CH-6110 Wolhusen, Switzerland

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 09期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

cell invasion; collagen scaffolds; interconnectivity; percolation; scaffold characterization; PORE-SIZE; MIGRATION; INTERCONNECTIVITY; MORPHOLOGY;

D O I：

10.1002/adhm.201500197

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion. © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1317 / 1321

页数：5

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