The Snail genes as inducers of cell movement and survival: implications in development and cancer

被引：1126
作者：
Barrallo-Gimeno, A [1 ]
Nieto, MA [1 ]
机构：
[1] UMH, CSIC, Inst Neurosci Alicante, Sant Joan dAlacant 03550, Spain
来源：
DEVELOPMENT | 2005年 / 132卷 / 14期
关键词：
D O I：
10.1242/dev.01907
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The functions of the Snail family of zinc-finger transcription factors are essential during embryonic development. One of their best-known functions is to induce epithelial to mesenchymal transitions (EMTs), which convert epithelial cells into migratory mesenchymal cells. In recent years, many orthologues of the Snail family have been identified throughout the animal kingdom, and their study is providing new clues about the EMT-dependent and-independent functions of Snail proteins. Here, we discuss these functions and how they influence cell behaviour during development and during diseases such as metastatic cancer. From these findings, we propose that Snail genes act primarily as survival factors and inducers of cell movement, rather than as inducers of EMT or cell fate.
引用
收藏
页码：3151 / 3161
页数：11
相关论文
共 105 条
  • [1] ALBERGA A, 1991, DEVELOPMENT, V111, P983
  • [2] Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition
    Bachelder, RE
    Yoon, SO
    Franci, C
    de Herreros, AG
    Mercurio, AM
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 168 (01) : 29 - 33
  • [3] Identification of neural crest competence territory: Role of Wnt signaling
    Bastidas, F
    De Calisto, J
    Mayor, R
    [J]. DEVELOPMENTAL DYNAMICS, 2004, 229 (01) : 109 - 117
  • [4] The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    Batlle, E
    Sancho, E
    Franci, C
    Domínguez, D
    Monfar, M
    Baulida, J
    de Herreros, AG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (02) : 84 - 89
  • [5] Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    Blanco, MJ
    Moreno-Bueno, G
    Sarrio, D
    Locascio, A
    Cano, A
    Palacios, J
    Nieto, MA
    [J]. ONCOGENE, 2002, 21 (20) : 3241 - 3246
  • [6] The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions:: a comparison with Snail and E47 repressors
    Bolós, V
    Peinado, H
    Pérez-Moreno, MA
    Fraga, MF
    Esteller, M
    Cano, A
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (03) : 499 - 511
  • [7] THE DROSOPHILA DEVELOPMENTAL GENE SNAIL ENCODES A PROTEIN WITH NUCLEIC-ACID BINDING FINGERS
    BOULAY, JL
    DENNEFELD, C
    ALBERGA, A
    [J]. NATURE, 1987, 330 (6146) : 395 - 398
  • [8] Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition
    Burstyn-Cohen, T
    Kalcheim, C
    [J]. DEVELOPMENTAL CELL, 2002, 3 (03) : 383 - 395
  • [9] The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    Cano, A
    Pérez-Moreno, MA
    Rodrigo, I
    Locascio, A
    Blanco, MJ
    del Barrio, MG
    Portillo, F
    Nieto, MA
    [J]. NATURE CELL BIOLOGY, 2000, 2 (02) : 76 - 83
  • [10] The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    Carver, EA
    Jiang, RL
    Lan, Y
    Oram, KF
    Gridley, T
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (23) : 8184 - 8188
12345678910