Highly Enantioselective Synthesis of Polysubstituted Tetrahydroquinolines via Organocatalytic Michael/Aza-Henry Tandem Reactions

被引：93

作者：

Jia, Zhen-Xin ^{[1
]}

Luo, Yong-Chun ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

关键词：

DIELS-ALDER REACTION; TRANSFER HYDROGENATION; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; DOMINO REACTIONS; FACILE SYNTHESIS; QUINOLINES; DERIVATIVES; ADDITIONS; 1,2,3,4-TETRAHYDROQUINOLINES;

D O I：

10.1021/ol103069d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantioselective chiral bifunctional thiourea catalyzed asymmetric tandem reactions for synthesis of substituted tetrahydroquinolines are described. Substituted tetrahydroquinolines were given in good yields (up to 98%), high enantioselectivities (up to >99% ee), and diastereoselectivities (up to 20:1 dr).

引用

页码：832 / 835

页数：4

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