Enzyme-Like Properties of Gold Clusters for Biomedical Application

被引:54
|
作者
Zhang, Yunguang [1 ]
Li, Shuo [1 ]
Liu, Haile [2 ,3 ]
Long, Wei [4 ]
Zhang, Xiao-Dong [2 ,3 ]
机构
[1] Xian Univ Posts & Telecommun, Sch Sci, Xian, Peoples R China
[2] Tianjin Univ, Dept Phys, Tianjin, Peoples R China
[3] Tianjin Univ, Sch Sci, Tianjin Key Lab Low Dimens Mat Phys & Preparing T, Tianjin, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Radiat Med, Tianjin, Peoples R China
来源
FRONTIERS IN CHEMISTRY | 2020年 / 8卷
基金
中国国家自然科学基金;
关键词
gold nanoclusters; nanozyme; enzyme-like properties; cancer therapy; bio-detection; PEROXIDASE-LIKE ACTIVITY; CATALYTIC-ACTIVITY; GLUCOSE-OXIDASE; SELECTIVE DETECTION; NANOPARTICLES; NANOCLUSTERS; SIZE; AU; GENERATION; WATER;
D O I
10.3389/fchem.2020.00219
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In recent years, the rapid development of nanoscience and technology has provided a new opportunity for the development and preparation of new inorganic enzymes. Nanozyme is a new generation of artificial mimetic enzyme, which like natural enzymes, can efficiently catalyze the substrate of enzyme under mild conditions, exhibiting catalytic efficiency, and enzymatic reaction kinetics similar to natural enzymes. However, nanozymes exist better stability than native enzymes, it can still maintain 85 % catalytic activity in strong acid and alkali (pH 2 similar to 10) or large temperature range (4 similar to 90 degrees C). This provides conditions for designing complex catalytic systems. In this review, we discussed the enzymatic attributes and biomedical applications of gold nanoclusters, including peroxidase-like, catalase-like, detection of heavy metal ions, and therapy of brain and cancer etc. This review can help us understand the current research status nanozymes.
引用
收藏
页数:13
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