Current advances on biological production of fumaric acid

被引：53

作者：

Guo, Feng ^{[1
]}

Wu, Min ^{[1
]}

Dai, Zhongxue ^{[1
]}

Zhang, Shangjie ^{[1
]}

Zhang, Wenming ^{[1
,2
]}

Dong, Weiliang ^{[1
,2
]}

Zhou, Jie ^{[1
,2
]}

Jiang, Min ^{[1
,2
]}

Xin, Fengxue ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Puzhu South Rd 30, Nanjing 211800, Peoples R China

[2] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 211800, Peoples R China

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2020年 / 153卷

基金：

中国国家自然科学基金;

关键词：

Fumaric acid; Strain improvement; Process development; Waste resources; IMMOBILIZED RHIZOPUS-ARRHIZUS; ENGINEERING ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; ASPERGILLUS-NIGER; PELLET FORMATION; LACTIC-ACID; MALIC-ACID; BIOTECHNOLOGICAL PRODUCTION; LIGNOCELLULOSIC BIOMASS; BIOCHEMICAL ASPECTS;

D O I：

10.1016/j.bej.2019.107397

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fumaric acid is an industrially important platform chemical, which has been widely used in food, chemicals, agriculture and pharmaceutical industries. Due to the rising price of raw materials in traditional petrochemical method and demand for sustainable development, fermentative fumaric acid production has attracted great attention. In this context, various strains with enhanced fumaric acid production or elimination of by-products were developed through mutagenesis or metabolic engineering. In addition, renewable organic wastes together with the fermentation process optimization have also been widely investigated. Accordingly, this review will comprehensively summarize the achievements of fermentative fumaric acid production in recent years and major obstacles occurring in industrialization to provide insights and perspective for future microbial fermentation of fumaric acid.

引用

页数：11

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