Myocardial localization of coronavirus in COVID-19 cardiogenic shock

被引：697

作者：

Tavazzi, Guido ^{[1
,2
]}

Pellegrini, Carlo ^{[1
,3
]}

Maurelli, Marco ^{[4
]}

Belliato, Mirko ^{[2
]}

Sciutti, Fabio ^{[2
]}

Bottazzi, Andrea ^{[2
]}

Sepe, Paola Alessandra ^{[5
]}

Resasco, Tullia ^{[5
]}

Camporotondo, Rita ^{[6
,7
]}

Bruno, Raffaele ^{[1
,8
]}

Baldanti, Fausto ^{[1
,9
]}

Paolucci, Stefania ^{[9
]}

Pelenghi, Stefano ^{[3
]}

Iotti, Giorgio Antonio ^{[1
,2
]}

Mojoli, Francesco ^{[1
,2
]}

Arbustini, Eloisa ^{[10
,11
]}

机构：

[1] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

[2] IRCCS Policlin San Matteo Fdn, ICU1 Dept Intens Med, Piazzale Golgi 19, I-27100 Pavia, Italy

[3] IRCCS Policlin San Matteo Fdn, Dept Intens Med, Cardiac Surg, Pavia, Italy

[4] IRCCS Policlin San Matteo Fdn, Dept Intens Med, ICU2, Pavia, Italy

[5] ASST, Osped Maggiore, Cardiol Unit, Lodi, Italy

[6] IRCCS Policlin San Matteo Fdn, Dept Med Sci & Infect Dis, Coronary Care Unit, Pavia, Italy

[7] IRCCS Policlin San Matteo Fdn, Dept Med Sci & Infect Dis, Lab Clin & Expt Cardiol, Pavia, Italy

[8] IRCCS Policlin San Matteo Fdn, Dept Med Sci & Infect Dis, Infect Dis 1, Pavia, Italy

[9] IRCCS Policlin San Matteo Fdn, Dept Diagnost Med, Mol Virol Unit, Pavia, Italy

[10] IRCCS Policlin San Matteo Fdn, Transplant Res Area, Dept Med Sci & Infect Dis, Piazzale Golgi 19, I-27100 Pavia, Italy

[11] IRCCS Policlin San Matteo Fdn, Ctr Inherited Cardiovasc Dis, Dept Med Sci & Infect Dis, Piazzale Golgi 19, I-27100 Pavia, Italy

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2020年 / 22卷 / 05期

关键词：

SARS-CoV-2; Coronavirus; Myocardial inflammation; Cardiac injury; Cardiogenic shock; Extracorporeal membrane oxygenation;

D O I：

10.1002/ejhf.1828

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

引用

页码：911 / 915

页数：5

共 15 条

[1] Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study [J].

Alsaad, Khaled O. ;

Hajeer, Ali H. ;

Al Balwi, Mohammed ;

Al Moaiqel, Mohammed ;

Al Oudah, Nourah ;

Al Ajlan, Abdulaziz ;

AlJohani, Sameera ;

Alsolamy, Sami ;

Gmati, Giamal E. ;

Balkhy, Hanan ;

Al-Jahdali, Hamdan H. ;

Baharoon, Salim A. ;

Arabi, Yaseen M. .

HISTOPATHOLOGY, 2018, 72 (03) :516-524

[2] Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study [J].

Ameri, Pietro ;

Inciardi, Riccardo M. ;

Di Pasquale, Mattia ;

Agostoni, Piergiuseppe ;

Bellasi, Antonio ;

Camporotondo, Rita ;

Canale, Claudia ;

Carubelli, Valentina ;

Carugo, Stefano ;

Catagnano, Francesco ;

Danzi, Giambattista ;

Dalla Vecchia, Laura ;

Giovinazzo, Stefano ;

Gnecchi, Massimiliano ;

Guazzi, Marco ;

Iorio, Anita ;

La Rovere, Maria Teresa ;

Leonardi, Sergio ;

Maccagni, Gloria ;

Mapelli, Massimo ;

Margonato, Davide ;

Merlo, Marco ;

Monzo, Luca ;

Mortara, Andrea ;

Nuzzi, Vincenzo ;

Piepoli, Massimo ;

Porto, Italo ;

Pozzi, Andrea ;

Provenzale, Giovanni ;

Sarullo, Filippo ;

Sinagra, Gianfranco ;

Tedino, Chiara ;

Tomasoni, Daniela ;

Volterrani, Maurizio ;

Zaccone, Gregorio ;

Lombardi, Carlo Mario ;

Senni, Michele ;

Metra, Marco .

CLINICAL RESEARCH IN CARDIOLOGY, 2021, 110 (07) :1020-1028

[3]

[Anonymous], 2020, JAMA, China, DOI DOI 10.1001/JAMA.2020.1585

[4]

Clerkin KJ, 2020, CIRCULATION

[5] Clinical Characteristics of Coronavirus Disease 2019 in China [J].

Guan, W. ;

Ni, Z. ;

Hu, Yu ;

Liang, W. ;

Ou, C. ;

He, J. ;

Liu, L. ;

Shan, H. ;

Lei, C. ;

Hui, D. S. C. ;

Du, B. ;

Li, L. ;

Zeng, G. ;

Yuen, K. -Y. ;

Chen, R. ;

Tang, C. ;

Wang, T. ;

Chen, P. ;

Xiang, J. ;

Li, S. ;

Wang, Jin-lin ;

Liang, Z. ;

Peng, Y. ;

Wei, L. ;

Liu, Y. ;

Hu, Ya-hua ;

Peng, P. ;

Wang, Jian-ming ;

Liu, J. ;

Chen, Z. ;

Li, G. ;

Zheng, Z. ;

Qiu, S. ;

Luo, J. ;

Ye, C. ;

Zhu, S. ;

Zhong, N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) :1708-1720

[6] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[7] Recognition and Initial Management of Fulminant Myocarditis A Scientific Statement From the American Heart Association [J].

Kociol, Robb D. ;

Cooper, Leslie T. ;

Fang, James C. ;

Moslehi, Javid J. ;

Pang, Peter S. ;

Sabe, Marwa A. ;

Shah, Ravi V. ;

Sims, Daniel B. ;

Thiene, Gaetano ;

Vardeny, Orly .

CIRCULATION, 2020, 141 (06) :E69-E92

[8] Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China [J].

Li, Bo ;

Yang, Jing ;

Zhao, Faming ;

Zhi, Lili ;

Wang, Xiqian ;

Liu, Lin ;

Bi, Zhaohui ;

Zhao, Yunhe .

CLINICAL RESEARCH IN CARDIOLOGY, 2020, 109 (05) :531-538

[9] Venoarterial Extracorporeal Membrane Oxygenation for Acute Fulminant Myocarditis in Adult Patients: A 5-Year Multi-Institutional Experience [J].

Lorusso, Roberto ;

Centofanti, Paolo ;

Gelsomino, Sandro ;

Barili, Fabio ;

Di Mauro, Michele ;

Orlando, Parise ;

Botta, Luca ;

Milazzo, Filippo ;

Dato, Guglielmo Actis ;

Casabona, Riccardo ;

Casali, Giovanni ;

Musumeci, Francesco ;

De Bonis, Michele ;

Zangrillo, Alberto ;

Alfieri, Ottavio ;

Pellegrini, Carlo ;

Mazzola, Sandro ;

Coletti, Giuseppe ;

Vizzardi, Enrico ;

Bianco, Roberto ;

Gerosa, Gino ;

Massetti, Massimo ;

Caldaroni, Federica ;

Pilato, Emanuele ;

Pacini, Davide ;

Di Bartolomeo, Roberto ;

Marinelli, Giuseppe ;

Sponga, Sandro ;

Livi, Ugolino ;

Mauro, Rinaldi ;

Mariscalco, Giovanni ;

Beghi, Cesare ;

Miceli, Antonio ;

Glauber, Mattia ;

Pappalardo, Federico ;

Russo, Claudio Francesco .

ANNALS OF THORACIC SURGERY, 2016, 101 (03) :919-926

[10] Preparing for the Most Critically Ill Patients With COVID-19 The Potential Role of Extracorporeal Membrane Oxygenation [J].

MacLaren, Graeme ;

Fisher, Dale ;

Brodie, Daniel .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (13) :1245-1246

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