Myocardial localization of coronavirus in COVID-19 cardiogenic shock

被引：690

作者：

Tavazzi, Guido ^{[1
,2
]}

Pellegrini, Carlo ^{[1
,3
]}

Maurelli, Marco ^{[4
]}

Belliato, Mirko ^{[2
]}

Sciutti, Fabio ^{[2
]}

Bottazzi, Andrea ^{[2
]}

Sepe, Paola Alessandra ^{[5
]}

Resasco, Tullia ^{[5
]}

Camporotondo, Rita ^{[6
,7
]}

Bruno, Raffaele ^{[1
,8
]}

Baldanti, Fausto ^{[1
,9
]}

Paolucci, Stefania ^{[9
]}

Pelenghi, Stefano ^{[3
]}

Iotti, Giorgio Antonio ^{[1
,2
]}

Mojoli, Francesco ^{[1
,2
]}

Arbustini, Eloisa ^{[10
,11
]}

机构：

[1] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

[2] IRCCS Policlin San Matteo Fdn, ICU1 Dept Intens Med, Piazzale Golgi 19, I-27100 Pavia, Italy

[3] IRCCS Policlin San Matteo Fdn, Dept Intens Med, Cardiac Surg, Pavia, Italy

[4] IRCCS Policlin San Matteo Fdn, Dept Intens Med, ICU2, Pavia, Italy

[5] ASST, Osped Maggiore, Cardiol Unit, Lodi, Italy

[6] IRCCS Policlin San Matteo Fdn, Dept Med Sci & Infect Dis, Coronary Care Unit, Pavia, Italy

[7] IRCCS Policlin San Matteo Fdn, Dept Med Sci & Infect Dis, Lab Clin & Expt Cardiol, Pavia, Italy

[8] IRCCS Policlin San Matteo Fdn, Dept Med Sci & Infect Dis, Infect Dis 1, Pavia, Italy

[9] IRCCS Policlin San Matteo Fdn, Dept Diagnost Med, Mol Virol Unit, Pavia, Italy

[10] IRCCS Policlin San Matteo Fdn, Transplant Res Area, Dept Med Sci & Infect Dis, Piazzale Golgi 19, I-27100 Pavia, Italy

[11] IRCCS Policlin San Matteo Fdn, Ctr Inherited Cardiovasc Dis, Dept Med Sci & Infect Dis, Piazzale Golgi 19, I-27100 Pavia, Italy

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2020年 / 22卷 / 05期

关键词：

SARS-CoV-2; Coronavirus; Myocardial inflammation; Cardiac injury; Cardiogenic shock; Extracorporeal membrane oxygenation;

D O I：

10.1002/ejhf.1828

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

引用

页码：911 / 915

页数：5

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