The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma

被引：19
作者：
Kim, Seung-Jae [1 ]
Moon, Hyung-Geun [1 ]
Park, Gye Young [1 ,2 ]
机构：
[1] Univ Illinois, Dept Med, Div Pulm Crit Care Sleep & Allergy, Chicago, IL 60607 USA
[2] Jesse Brown Vet Affairs Med Ctr, Chicago, IL USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2020年 / 1865卷 / 05期
关键词：
Lysophosphatidic acid; Autotaxin; Asthma; Lysophosphatidic acid receptors; Airway inflammation; EXTRACELLULAR LYSOPHOSPHATIDIC ACID; HUMAN MONOCYTE CHEMOTAXIS; AUTOTAXIN EXPRESSION; DENDRITIC CELLS; PPAR-GAMMA; SPHINGOSINE; 1-PHOSPHATE; LYSOPHOSPHOLIPASE-D; RECEPTOR; LPA; ACTIVATION;
D O I：
10.1016/j.bbalip.2020.158641
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysophosphatidic acid (LPA) species are present in almost all organ systems and play diverse roles through its receptors. Asthma is an airway disease characterized by chronic allergic inflammation where various innate and adaptive immune cells participate in establishing Th2 immune response. Here, we will review the contribution of LPA and its receptors to the functions of immune cells that play a key role in establishing allergic airway inflammation and aggravation of allergic asthma.
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