The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma

被引：19

作者：

Kim, Seung-Jae ^{[1
]}

Moon, Hyung-Geun ^{[1
]}

Park, Gye Young ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Med, Div Pulm Crit Care Sleep & Allergy, Chicago, IL 60607 USA

[2] Jesse Brown Vet Affairs Med Ctr, Chicago, IL USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2020年 / 1865卷 / 05期

关键词：

Lysophosphatidic acid; Autotaxin; Asthma; Lysophosphatidic acid receptors; Airway inflammation; EXTRACELLULAR LYSOPHOSPHATIDIC ACID; HUMAN MONOCYTE CHEMOTAXIS; AUTOTAXIN EXPRESSION; DENDRITIC CELLS; PPAR-GAMMA; SPHINGOSINE; 1-PHOSPHATE; LYSOPHOSPHOLIPASE-D; RECEPTOR; LPA; ACTIVATION;

D O I：

10.1016/j.bbalip.2020.158641

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysophosphatidic acid (LPA) species are present in almost all organ systems and play diverse roles through its receptors. Asthma is an airway disease characterized by chronic allergic inflammation where various innate and adaptive immune cells participate in establishing Th2 immune response. Here, we will review the contribution of LPA and its receptors to the functions of immune cells that play a key role in establishing allergic airway inflammation and aggravation of allergic asthma.

引用

页数：8

共 133 条

[1] Polyunsaturated lysophosphatidic acid as a potential asthma biomarker [J].

Ackerman, Steven J. ;

Park, Gye Young ;

Christman, John W. ;

Nyenhuis, Sharmilee ;

Berdyshev, Evgeny ;

Natarajan, Viswanathan .

BIOMARKERS IN MEDICINE, 2016, 10 (02) :123-135

[2] Understanding high endothelial venules: Lessons for cancer immunology [J].

Ager, Ann ;

May, Michael J. .

ONCOIMMUNOLOGY, 2015, 4 (06)

[3] JB Special Review-Recent Progress in Lipid Mediators Lysophosphatidic acid as a lipid mediator with multiple biological actions [J].

Aikawa, Shizu ;

Hashimoto, Takafumi ;

Kano, Kuniyuki ;

Aoki, Junken .

JOURNAL OF BIOCHEMISTRY, 2015, 157 (02) :81-89

[4] Lysophosphatidic acid accelerates the development of human mast cells [J].

Bagga, S ;

Price, KS ;

Lin, DA ;

Friend, DS ;

Austen, KF ;

Boyce, JA .

BLOOD, 2004, 104 (13) :4080-4087

[5] Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation [J].

Benesch, Matthew G. K. ;

MacIntyre, Iain T. K. ;

McMullen, Todd P. W. ;

Brindley, David N. .

CANCERS, 2018, 10 (03)

[6] Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate [J].

Benesch, Matthew G. K. ;

Zhao, Yuan Y. ;

Curtis, Jonathan M. ;

McMullen, Todd P. W. ;

Brindley, David N. .

JOURNAL OF LIPID RESEARCH, 2015, 56 (06) :1134-1144

[7] Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions [J].

Benesch, Matthew G. K. ;

Ko, Yi M. ;

McMullen, Todd P. W. ;

Brindley, David N. .

FEBS LETTERS, 2014, 588 (16) :2712-2727

[8] Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation [J].

Bot, Martine ;

de Jager, Saskia C. A. ;

MacAleese, Luke ;

Lagraauw, H. Maxime ;

van Berkel, Theo J. C. ;

Quax, Paul H. A. ;

Kuiper, Johan ;

Heeren, Ron M. A. ;

Biessen, Erik A. L. ;

Bot, Ilze .

JOURNAL OF LIPID RESEARCH, 2013, 54 (05) :1265-1274

[9] RAGE-induced asthma: A role for the receptor for advanced glycation end-products in promoting allergic airway disease [J].

Brandt, Eric B. ;

Lewkowich, Ian P. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 144 (03) :651-653

[10] Lipid phosphate phosphatases and signaling [J].

Brindley, David N. ;

Pilquil, Carlos .

JOURNAL OF LIPID RESEARCH, 2009, 50 :S225-S230

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