Autoantigen specific IL-2 activated CD4+ CD25+T regulatory cells inhibit induction of experimental autoimmune neuritis

被引：12
作者：
Tran, Giang T. [1 ]
Hodgkinson, Suzanne J. [1 ,2 ]
Carter, Nicole [1 ,4 ]
Verma, Nirupama D. [1 ]
Robinson, Catherine M. [1 ]
Plain, Karren M. [1 ,4 ]
Nomura, Masaru [1 ,5 ]
Hall, Bruce M. [1 ,3 ]
机构：
[1] UNSW Sydney, Ingham Inst, Immune Tolerance Lab, Fac Med, Liverpool, NSW, Australia
[2] Liverpool Hlth Serv, Dept Neurol, Liverpool, NSW, Australia
[3] Liverpool Hlth Serv, Dept Nephrol, Liverpool, NSW, Australia
[4] Univ Sydney, Fac Sci, Sydney Sch Vet Sci, 425 Werombi Rd, Camden, NSW, Australia
[5] Keiwakai Ebetsus Hosp, Dept Surg, Nopporro Yoyogicho 81-7, Ebetsu, Hokkaido 0690817, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 341卷
关键词：
T regulatory cells; Interleukin-2; Autoimmunity; Experimental autoimmune neuritis; EXPERIMENTAL ALLERGIC NEURITIS; CARDIAC ALLOGRAFT SURVIVAL; INDUCED TREG CELLS; T-CELLS; TGF-BETA; IFN-GAMMA; IN-VIVO; IMMUNE-RESPONSES; CELLULAR BASIS; CUTTING EDGE;
D O I：
10.1016/j.jneuroim.2020.577186
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Experimental autoimmune neuritis (EAN) induced by peripheral nerve myelin (PNM) is self-limiting and reimmunization with PNM does not re-activate disease. This study showed inhibition of EAN by CD4(+) CD25(+)T cells both from sensitized hosts or from naive hosts after ex-vivo activation by PNM and rIL-2. Transfer of naive CD4(+) CD25(+)T cells has no effect on EAN, nor did naive CD4(+) CD25(+)T cells activated with rIL-2 and renal tubular antigen. Culture of naive CD4(+) CD25(+)Treg with rIL-2 and PNM induced mRNA for the IFN-gamma receptor. We showed naive CD4(+) CD25(+)T cells activated by specific auto-antigen and rIL-2 produced more potent antigen-specific Treg that may have therapeutic potential.
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页数：9
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