Trained Immunity and Local Innate Immune Memory in the Lung

被引：63

作者：

Netea, Mihai G. ^{[1
,2
,3
]}

Joosten, Leo A. B. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[3] Univ Bonn, Dept Immunol & Metab, Life & Med Sci Inst LIMES, D-53115 Bonn, Germany

来源：

CELL | 2018年 / 175卷 / 06期

基金：

欧洲研究理事会;

关键词：

D O I：

10.1016/j.cell.2018.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFN gamma release from effector CD8(+) lymphocytes initiating this process.

引用

页码：1463 / 1465

页数：4

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