The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer

被引：4
作者：
Fu, X. -M. [1 ]
Guo, W. [2 ]
Li, N. [1 ]
Liu, H. -Z. [3 ]
Liu, J. [4 ]
Qiu, S. -Q. [5 ]
Zhang, Q. [6 ]
Wang, L. -C. [7 ]
Li, F. [8 ]
Li, C. -L. [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Endocrinol, Beijing, Peoples R China
[2] Fuzhou Gen Hosp Nanjing Mil Command, Dept Endocrinol, Fuzhou, Fujian, Peoples R China
[3] Cent Hosp Handan City, Dept Med Record Management, Handan, Hebei, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing, Peoples R China
[5] Johns Hopkins Univ, Dept Pediat, Div Endocrinol & Metab, Baltimore, MD 21218 USA
[6] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
[7] Air Force Gen Hosp PLA, Dept Endocrinol, Beijing, Peoples R China
[8] Army Gen Hosp PLA, Dept Hlth Care, Beijing, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2017年 / 21卷 / 14期
关键词：
Long noncoding RNA; lncRNA-ATB; Papillary thyroid cancer; Proliferation; Migration; INVASION-METASTASIS CASCADE; SERUM THYROGLOBULIN; POOR-PROGNOSIS; TGF-BETA; PROMOTES; CARCINOMA; PROLIFERATION; PROGRESSION; PREDICTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: This study aimed to investigate the expression and clinical significances of long noncoding RNA-ATB (lncRNA-ATB) in papillary thyroid cancer (PTC), and to explore the roles of lncRNA-ATB in PTC cell proliferation and migration. PATIENTS AND METHODS: The expression of lncRNA-ATB in 64 PTC tissues and paired adjacent noncancerous thyroid tissues was measured. The association between lncRNA-ATB expression and clinicopathological characteristics was analyzed by Pearson X2. The diagnostic value of lncRNA-ATB was evaluated by receiver operating characteristic curve (ROC) analyses. The effects of lncRNA-ATB on PTC cell proliferation were evaluated by Cell Counting Kit-8 assays and Ethynyl deoxyuridine incorporation assays. The effects of lncRNA-ATB on PTC cell migration were evaluated by transwell assays. RESULTS: LncRNA-ATB is upregulated in PTC tissues compared with noncancerous tissues. LncRNA-ATB is also increased in PTC cell lines compared with normal thyroid follicular epithelial cell line. High-expression of lncRNA-ATB is associated with large tumor size and lymph node metastasis. ROC analyses revealed that lncRNA-ATB could sensitively discriminate PTCs from noncancerous tissues, as well as discriminating PTCs with lymph node metastasis from those without lymph node metastasis. Functional experiments showed that depletion of lncRNA-ATB significantly inhibits PTC cell proliferation and migration. CONCLUSIONS: LncRNA-ATB is upregulated and functions as an oncogene in PTC. Furthermore, lncRNA-ATB may serve as a diagnostic biomarker and therapeutic target for PTC.
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收藏
页码：3239 / 3246
页数：8
相关论文
共 34 条
[1]  
[Anonymous], SCI REP UK
[2]  
Ansari M, 2014, EUR REV MED PHARMACO, V18, P1925
[3]   Thyroid Cancer Incidence Patterns in the United States by Histologic Type, 1992-2006 [J].
Aschebrook-Kilfoy, Briseis ;
Ward, Mary H. ;
Sabra, Mona M. ;
Devesa, Susan S. .
THYROID, 2011, 21 (02) :125-134
[4]   Long Noncoding RNAs: Cellular Address Codes in Development and Disease [J].
Batista, Pedro J. ;
Chang, Howard Y. .
CELL, 2013, 152 (06) :1298-1307
[5]   Differentiated Thyroid Cancer [J].
Burns, William R. ;
Zeiger, Martha A. .
SEMINARS IN ONCOLOGY, 2010, 37 (06) :557-566
[6]   Landscape of transcription in human cells [J].
Djebali, Sarah ;
Davis, Carrie A. ;
Merkel, Angelika ;
Dobin, Alex ;
Lassmann, Timo ;
Mortazavi, Ali ;
Tanzer, Andrea ;
Lagarde, Julien ;
Lin, Wei ;
Schlesinger, Felix ;
Xue, Chenghai ;
Marinov, Georgi K. ;
Khatun, Jainab ;
Williams, Brian A. ;
Zaleski, Chris ;
Rozowsky, Joel ;
Roeder, Maik ;
Kokocinski, Felix ;
Abdelhamid, Rehab F. ;
Alioto, Tyler ;
Antoshechkin, Igor ;
Baer, Michael T. ;
Bar, Nadav S. ;
Batut, Philippe ;
Bell, Kimberly ;
Bell, Ian ;
Chakrabortty, Sudipto ;
Chen, Xian ;
Chrast, Jacqueline ;
Curado, Joao ;
Derrien, Thomas ;
Drenkow, Jorg ;
Dumais, Erica ;
Dumais, Jacqueline ;
Duttagupta, Radha ;
Falconnet, Emilie ;
Fastuca, Meagan ;
Fejes-Toth, Kata ;
Ferreira, Pedro ;
Foissac, Sylvain ;
Fullwood, Melissa J. ;
Gao, Hui ;
Gonzalez, David ;
Gordon, Assaf ;
Gunawardena, Harsha ;
Howald, Cedric ;
Jha, Sonali ;
Johnson, Rory ;
Kapranov, Philipp ;
King, Brandon .
NATURE, 2012, 489 (7414) :101-108
[7]  
Elboga U, 2015, EUR REV MED PHARMACO, V19, P396
[8]   Long noncoding RNA activated by TGF-β in human cancers: A meta-analysis [J].
Fan, Yang-Hua ;
Ji, Chen-xing ;
Xu, Bing ;
Fan, Heng-yi ;
Cheng, Zu-jue ;
Zhu, Xin-Gen .
CLINICA CHIMICA ACTA, 2017, 468 :10-16
[9]   Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 [J].
Ferlay, Jacques ;
Shin, Hai-Rim ;
Bray, Freddie ;
Forman, David ;
Mathers, Colin ;
Parkin, Donald Maxwell .
INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) :2893-2917
[10]   MALAT1 promotes the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1 [J].
Huang, Jian-kang ;
Ma, Ling ;
Song, Wen-hua ;
Lu, Bang-yu ;
Huang, Yu-bin ;
Dong, Hui-ming ;
Ma, Xiao-kai ;
Zhu, Zheng-zhi ;
Zhou, Rui .
BIOMEDICINE & PHARMACOTHERAPY, 2016, 83 :1-7
1234