Copper-Catalyzed Domino Addition, Hydroamination, and Cyclization: A Multicomponent Approach to Spiro Oxazolidinone Derivatives

被引：20
|
作者：
Potuganti, Gal Reddy [1 ,3 ]
Indukuri, Divakar Reddy [1 ,3 ]
Nanubolu, Jagadeesh Babu [2 ]
Alla, Manjula [1 ,3 ]
机构：
[1] Indian Inst Chem Technol, Fluoroagrochem Div, CSIR, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Chem Technol, CSIR, Ctr Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India
[3] Indian Inst Chem Technol, CSIR, Acad Sci & Innovat Res, Hyderabad 500007, Andhra Pradesh, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 24期
关键词：
C-H ACTIVATION; PROPARGYLIC ALCOHOLS; ASYMMETRIC ALKYNYLATION; EFFICIENT; ISOCYANATE; ALDEHYDES; HALIDES; KETONES; ALKYNE;
D O I：
10.1021/acs.joc.8b02461
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed one-pot multicomponent protocol has been developed for construction of spiro heterocycles. The domino approach leads to the synthesis of spiro oxazolidinones starting from ketones, arylacetylenes, and isocyanates via catalytic addition, hydroamination, and cyclization involving consecutive C-C, C-O, and C-N bond formations.
引用
收藏
页码：15186 / 15194
页数：9
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