Influence of Advanced Age on Mycobacterium bovis BCG Vaccination in Guinea Pigs Aerogenically Infected with Mycobacterium tuberculosis

被引：7
|
作者：
Komine-Aizawa, Shihoko [1 ,2 ]
Yamazaki, Toshio [3 ]
Yamazaki, Tsuyoshi [8 ]
Hattori, Shin-ichiro [2 ,9 ]
Miyamoto, Yuji [4 ]
Yamamoto, Naoki [2 ,10 ]
Haga, Shinji [5 ]
Sugitani, Masahiko [6 ]
Honda, Mitsuo [2 ]
Hayakawa, Satoshi [2 ]
Yamamoto, Saburo [7 ]
机构：
[1] Nihon Univ, Sch Med, Div Microbiol, Itabashi Ku,Dept Pathol & Microbiol,Natl Inst Inf, Tokyo, Japan
[2] Nihon Univ, Sch Med, AIDS Res Ctr, Tokyo, Japan
[3] Nihon Univ, Sch Med, Div Biosafety Control & Res, Tokyo, Japan
[4] Nihon Univ, Sch Med, Leprosy Res Ctr, Dept Mycobacteriol, Tokyo, Japan
[5] Nihon Univ, Sch Med, Dept Bacteriol, Tokyo, Japan
[6] Nihon Univ, Sch Med, Div Pathol, Dept Pathol & Microbiol, Tokyo, Japan
[7] Japan BCG Lab, Tokyo, Japan
[8] Tokai Univ, Sch High Technol Human Welf, Kanagawa 2591100, Japan
[9] Kumamoto Univ, Ctr AIDS Res, Div Hematopoiesis, Kumamoto, Japan
[10] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Singapore 117595, Singapore
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2010年 / 17卷 / 10期
关键词：
CD8; T-CELLS; OLD MICE; PULMONARY TUBERCULOSIS; EARLY RESISTANCE; IMMUNE-RESPONSE; GAMMA-INTERFERON; REVACCINATION; CHILDREN; MODEL; METAANALYSIS;
D O I：
10.1128/CVI.00190-10
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycobacterium bovis bacillus Calmette-Guerin (BCG) is the only tuberculosis (TB) vaccine currently available, but its efficacy against adult pulmonary TB remains controversial. BCG induces specific immune responses to mycobacterial antigens and may elicit protective immunity against TB. TB remains a major public health problem, especially among the elderly, yet the efficacy of BCG in the elderly is unknown. We investigated the ability of BCG vaccination to prevent TB in young (6-week-old), middle-aged (18-month-old), and old (60-month-old) guinea pigs. BCG-Tokyo vaccination reduced the growth of Mycobacterium tuberculosis H37Rv in all three groups. By use of an enzyme-linked immunospot (ELISPOT) assay, antigen-specific gamma interferon (IFN-gamma)-producing cells were detected in the 60-month-old guinea pigs after a booster vaccination with BCG-Tokyo. Our findings suggest that BCG-Tokyo has a protective effect against tuberculosis infection regardless of age.
引用
收藏
页码：1500 / 1506
页数：7
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