Cardioprotection by 6-gingerol in diabetic rats

被引：20
作者：
El-Bassossy, Hany M. [1 ,2 ]
Elberry, Ahmed A. [3 ,4 ]
Ghareib, Salah A. [1 ]
Azhar, Ahmad [5 ]
Banjar, Zainy Mohammed [6 ]
Watson, Malcolm L. [7 ]
机构：
[1] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah 21589, Saudi Arabia
[2] Zagazig Univ, Dept Pharmacol, Fac Pharm, Zagazig, Egypt
[3] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia
[4] Beni Suef Univ, Fac Med, Dept Pharmacol, Bani Suwayf, Egypt
[5] King Abdulaziz Univ, Fac Med, Dept Pediat Cardiol, Jeddah 21589, Saudi Arabia
[6] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah 21589, Saudi Arabia
[7] Univ Bath, Dept Pharm & Pharmacol, Bath, Avon, England
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2016年 / 477卷 / 04期
关键词：
Diabetes; 6-Gingerol; Cardioprotection; Adiponectin; Vascular complications; Hemodynamics; Electrocardiogram; MYOCARDIAL-INFARCTION; ZINGIBER-OFFICINALE; OXIDATIVE STRESS; QTC INTERVAL; CELL-DEATH; TGF-BETA; IN-VIVO; STREPTOZOTOCIN; CARDIOMYOPATHY; MECHANISMS;
D O I：
10.1016/j.bbrc.2016.06.157
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally). After a further 8 weeks, blood was collected for biochemical analysis and 8-isoprostenol was measured in urine. Cardiac hemodynamics and ECG was assessed. 6G significantly attenuated the increased level of blood glucose in diabetic rats and improved cardiac hemodynamics in including RR interval, max dP/dt, min dP/dt and Tau. In addition, 6G alleviated the elevated ST segment, T amplitude and R amplitude with no significant effect on disturbed levels of adiponectin, TGF-beta or 8-isoprostenol induced by diabetes. The results showed that treatment with 6G has an ameliorative effect on cardiac dysfunction induced by diabetes. Which may be not related to its potential antioxidant effect. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：908 / 914
页数：7
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