DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

被引：422
作者：
Durocher, D
Jackson, SP
机构：
[1] Univ Cambridge, Wellcome Trust & Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Zool, Cambridge CB2 1QR, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(00)00201-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.
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页码：225 / 231
页数：7
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