Mechanisms of translational regulation in Drosophila

被引：71
作者：
Wilhelm, JE
Smilbert, CA [1 ]
机构：
[1] Carnegie Inst Sci, Dept Embryol, Baltimore, MD 21210 USA
[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada
来源：
BIOLOGY OF THE CELL | 2005年 / 97卷 / 04期
关键词：
cup; Drosophila fragile x mental retardation 1 (dFMR1); RNA interference (RNAi); Smaug; sex-lethal;
D O I：
10.1042/BC20040097
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Translational regulation plays an essential role in many phases of the Drosophila life cycle. During embryogenesis, specification of the developing body pattern requires co-ordination of the translation of oskar, gurken and nanos mRNAs with their subcellular localization. In addition, dosage compensation is controlled by Sex-lethal-mediated translational regulation while dFMR1 (the Drosophila homologue of the fragile X mental retardation protein) controls translation of various mRNAs which function in the nervous system. Here we describe some of the mechanisms that are utilized to regulate these various processes. Our review highlights the complexity that can be involved with multiple factors employing different mechanisms to control the translation of a single mRNA.
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收藏
页码：235 / 252
页数：18
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