A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones

被引：11
|
作者：
Cuthbertson, James D. [1 ]
Godfrey, Andrew A. [2 ]
Taylor, Richard J. K. [1 ]
机构：
[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
[2] AstraZeneca, Pharmaceut Dev, Macclesfield SK10 2NA, Cheshire, England
来源：
SYNLETT | 2010年 / 18期
基金：
英国工程与自然科学研究理事会;
关键词：
amination; lactamisation; azabicyclo[2.2.2]octanones; bicyclic compounds; 6-carboalkoxycyclohex-2-enones;
D O I：
10.1055/s-0030-1258811
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.
引用
收藏
页码：2805 / 2807
页数：3
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