Enantioselective intramolecular Rauhut-Currier reaction catalyzed by chiral phosphinothiourea

被引：71
|
作者：
Gong, Jing-Jing [1 ,2 ]
Li, Tian-Ze [1 ,2 ]
Pan, Kun [1 ,2 ]
Wu, Xin-Yan [1 ,2 ,3 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China
[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MORITA-BAYLIS-HILLMAN; AMINO-ACID; PHOSPHINES; CYSTEINE;
D O I：
10.1039/c0cc04412a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chiral organophosphine-catalyzed enantioselective Rauhut-Currier reaction has been disclosed for the first time. With L-valine-derived phosphinothiourea, the intramolecular Rauhut-Currier reaction of bis(enones) was achieved in good yields (up to 99%) with excellent enantioselectivities (up to 99.4% ee).
引用
收藏
页码：1491 / 1493
页数：3
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