Dectin-1 deficiency does not affect atherosclerosis development in mice

被引：13

作者：

Szilagyi, Katka ^{[1
]}

Gijbels, Marion J. J. ^{[2
,3
,4
]}

van der Velden, Saskia ^{[2
]}

Heinsbroek, Sigrid E. M. ^{[5
]}

Kraal, Georg ^{[6
]}

de Winther, Menno P. J. ^{[2
]}

van den Berg, Timo K. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Blood Cell Res, Sanquin Res & Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, Expt Vasc Biol, NL-1105 AZ Amsterdam, Netherlands

[3] Maastricht Univ, Cardiovasc Res Inst Maastricht, CARIM, Dept Pathol, NL-6200 MD Maastricht, Netherlands

[4] Maastricht Univ, Cardiovasc Res Inst Maastricht, CARIM, Dept Mol Genet, NL-6200 MD Maastricht, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 AZ Amsterdam, Netherlands

[6] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

来源：

ATHEROSCLEROSIS | 2015年 / 239卷 / 02期

关键词：

Dectin-1; Atherosclerosis; Macrophages; Respiratory burst; BETA-GLUCAN RECEPTOR; MACROPHAGES; VIMENTIN; RECOGNITION;

D O I：

10.1016/j.atherosclerosis.2015.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. Methods: Using immunohistochemistry dectin-1 expression was observed on foamy macrophages in atherosclerotic lesions in mice. Following lethal irradiation LDLR-/- mice were reconstituted with bone marrow from either wild type or dectin-1(-/-) mice. After recovery, mice were fed a high fat diet for 9 weeks and atherosclerotic lesions were analyzed. Results and conclusion: Overall, we found no significant differences in plaque size or severity between the groups. Also no differences were observed in granulocyte or macrophage composition of the plaques or in the ability to produce reactive oxygen species by macrophages from both groups. Dectin-1 is dispensable for the development of atherosclerotic lesions in mice. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：318 / 321

页数：4

共 10 条

[1] Dectin-1 is a major β-glucan receptor on macrophages [J].