The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials

被引：106

作者：

Suder, Ellen ^{[1
]}

Furuyama, Wakako ^{[1
]}

Feldmann, Heinz ^{[1
]}

Marzi, Andrea ^{[1
]}

de Wit, Emmie ^{[1
]}

机构：

[1] NIAID, Lab Virol, NIH, Rocky Mt Labs, Hamilton, MT 59840 USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2018年 / 14卷 / 09期

关键词：

VSV-EBOV; animal models; clinical trials; filovirus; preclinical testing; phase; 1; 2; 3; PROTECTS NONHUMAN-PRIMATES; MARBURG VIRUS; DOUBLE-BLIND; CHALLENGE; SAFETY; IMMUNOGENICITY; EFFICACY; IMMUNIZATION; ANTIBODIES; INFECTION;

D O I：

10.1080/21645515.2018.1473698

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The devastating Ebola virus (EBOV) epidemic in West Africa in 2013-2016 accelerated the progress of several vaccines and antivirals through clinical trials, including the replication-competent vesicular stomatitis virus-based vaccine expressing the EBOV glycoprotein (VSV-EBOV). Extensive preclinical testing in animal models demonstrated the prophylactic and post-exposure efficacy of this vaccine, identified the mechanism of protection, and suggested it was safe for human use. Based on these data, VSV-EBOV was extensively tested in phase 1-3 clinical trials in North America, Europe and Africa. Although some side effects of vaccination were observed, these clinical trials showed that the VSV-EBOV was safe and immunogenic in humans. Moreover, the data supported the use of VSV-EBOV as an emergency vaccine in individuals at risk for Ebola virus disease. In this review, we summarize the results of the extensive preclinical and clinical testing of the VSV-EBOV vaccine.

引用

页码：2107 / 2113

页数：7

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