PET probe-guided surgery

被引：29

作者：

Gulec, Seza A. ^{[1
]}

机构：

[1] Goshen Hlth Syst, Ctr Canc Care, Goshen, IN USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2007年 / 96卷 / 04期

关键词：

target to background ratio; recurrent/metastatic lesions; gamma probe;

D O I：

10.1002/jso.20862

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intraoperative localization of PET-positive recurrent/metastatic lesions can be facilitated using a hand-held PET probe. PET probe is a high-energy gamma probe designed to process the 511 keV photons of PET tracers. Intraoperative gamma probe performance is a function of radiopharmaceutical uptake, clearance kinetics, and probe engineering, all determining the target to background ratio (TBR) and detection threshold. A minimum TBR of 1.5:1 is needed in the operative field for the operating surgeon to be comfortable the differences between tumor tissue and normal adjacent tissue are real. Due to high-energy photon fluxes, achieving a satisfactory TBR intraoperatively is challenging and requires development of a clinically feasible PET-probe guided surgery protocol.

引用

页码：353 / 357

页数：5

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