Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

被引:26
作者
Chen, Qin-Fen [1 ]
Zhou, Xiao-Dong [2 ]
Sun, Yang-Jie [1 ]
Fang, Dan-Hong [3 ]
Zhao, Qian [1 ]
Huang, Jun-Hua [1 ]
Jin, Yin [1 ]
Wu, Jian-Sheng [3 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Cardiovasc Med, Wenzhou 325000, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 1, Med & Hlth Care Ctr, Wenzhou 325000, Zhejiang, Peoples R China
关键词
Non-alcoholic fatty liver disease; Health-check; Adenomatous polyps; Hyperplastic polyps; INSULIN-RESISTANCE; METABOLIC SYNDROME; FOLLOW-UP; NAFLD; RISK; CHINESE; PREVALENCE; DYSLIPIDEMIA; ADIPONECTIN; ONCOPROTEIN;
D O I
10.3748/wjg.v23.i28.5206
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps. METHODS A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colono-scopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps. RESULTS The prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95% CI: 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95% CI: 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95% CI: 1.18-2.00, P < 0.05; OR = 1.42, 95% CI: 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95% CI: 0.18-1.04, P > 0.05; OR = 1.18, 95% CI: 0.50-2.78, P > 0.05). CONCLUSION NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women.
引用
收藏
页码:5206 / 5215
页数:10
相关论文
共 46 条
[1]  
[Anonymous], ONCOTARGET
[2]   Global patterns and trends in colorectal cancer incidence and mortality [J].
Arnold, Melina ;
Sierra, Monica S. ;
Laversanne, Mathieu ;
Soerjomataram, Isabelle ;
Jemal, Ahmedin ;
Bray, Freddie .
GUT, 2017, 66 (04) :683-691
[3]   BCL-2 ONCOPROTEIN IN COLORECTAL HYPERPLASTIC POLYPS, ADENOMAS, AND ADENOCARCINOMAS [J].
BOSARI, S ;
MONEGHINI, L ;
GRAZIANI, D ;
LEE, AKC ;
MURRAY, JJ ;
COGGI, G ;
VIALE, G .
HUMAN PATHOLOGY, 1995, 26 (05) :534-540
[4]   Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms [J].
Bugianesi, E ;
Gastaldelli, A ;
Vanni, E ;
Gambino, R ;
Cassader, M ;
Baldi, S ;
Ponti, V ;
Pagano, G ;
Ferrannini, E ;
Rizzetto, M .
DIABETOLOGIA, 2005, 48 (04) :634-642
[5]   Non-alcoholic fatty liver disease in the Asia-Pacific region: Definitions and overview of proposed guidelines [J].
Chitturi, Shivakumar ;
Farrell, Geoffrey C. ;
Hashimoto, Etsuko ;
Saibara, Toshiji ;
Lau, George K. K. ;
Sollano, Jose D. .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 (06) :778-787
[6]  
Croizet O, 1997, GASTROINTEST ENDOSC, V46, P119
[7]   Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease [J].
Gaggini, Melania ;
Morelli, Mariangela ;
Buzzigoli, Emma ;
DeFronzo, Ralph A. ;
Bugianesi, Elisabetta ;
Gastaldelli, Amalia .
NUTRIENTS, 2013, 5 (05) :1544-1560
[8]   The metabolic syndrome as a predictor of nonalcoholic fatty liver disease [J].
Hamaguchi, M ;
Kojima, T ;
Takeda, N ;
Nakagawa, T ;
Taniguchi, H ;
Fujii, K ;
Omatsu, T ;
Nakajima, T ;
Sarui, H ;
Shimazaki, M ;
Kato, T ;
Okuda, J ;
Ida, K .
ANNALS OF INTERNAL MEDICINE, 2005, 143 (10) :722-728
[9]   Origin of colorectal cancers in hyperplastic polyps and serrated adenomas: Another truism bites the dust [J].
Hamilton, SR .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (17) :1282-1283
[10]   Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas [J].
Hawkins, NJ ;
Ward, RL .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (17) :1307-1313