The expression of seven 14-3-3 isoforms in human meningioma

被引：28

作者：

Liu, Yang ^{[1
]}

Tian, Rui-feng ^{[2
]}

Li, Yun-ming ^{[3
]}

Liu, Wei-ping ^{[1
]}

Cao, Lei ^{[1
]}

Yang, Xiao-liang ^{[1
]}

Cao, Wei-dong ^{[1
]}

Zhang, Xiang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dist Retired Cadres Entertainment Ctr, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Dept Hlth Stat, Xian 710032, Peoples R China

来源：

BRAIN RESEARCH | 2010年 / 1336卷

关键词：

14-3-3; isoforms; Meningioma; Immunohistochemistry; PROTEINS; 14-3-3-PROTEINS; CANCER; APOPTOSIS; TERMINUS; BINDING; AKT;

D O I：

10.1016/j.brainres.2010.04.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

14-3-3 proteins comprise a large family of highly conserved, acidic polypeptides, expressed in all eukaryotic organisms, with highest concentration found in the brain. Multiple isoforms of 14-3-3 proteins have been shown to play an essential role in regulating differentiation, proliferation and transformation. In the previous study, the expression levels of all seven 14-3-3 isoforms were examined in astrocytoma. However, the expression of seven 14-3-3 isoforms in meningioma still remains unknown. This study is the first examination of 14-3-3 isoforms in three grades of meningioma by immunohistochemistry. 14-3-3 epsilon, zeta and theta were specifically expressed in meningioma, and their expression levels increased with the increase of pathological grade of meningioma. The 14-3-3 eta, beta, gamma and sigma isoforms were negatively expressed in meningioma. In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：98 / 102

页数：5

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