Analysis of chromosomal imbalances by comparative genomic hybridisation of pigmented villonodular synovitis

被引：5

作者：

Berger, I ^{[1
]}

Rieker, R ^{[1
]}

Ehemann, V ^{[1
]}

Schmitz, W ^{[1
]}

Autschbach, F ^{[1
]}

Weckauf, H ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany

来源：

CANCER LETTERS | 2005年 / 220卷 / 02期

关键词：

pigmented villonodular synovitis; chromosomal imbalances; CGH;

D O I：

10.1016/j.canlet.2004.08.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using comparative genomic hybridisation, DNA copy number changes were investigated in 15 cases of pigmented villonodular synovitis of the knee joint. Additionally DNA content was analysed by flow cytometry. Screening revealed numerical chromosomal imbalances in five of the examined cases. A total number of 18 gains were detected. The most frequent gains involved subregions of chromosomal arms 22q and 16p and 16q. No losses were found. One of the cases showed an aneuploid DNA-pattern, which actually proved to be the case with the most numerical chromosomal changes. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：231 / 236

页数：6

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