Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells

被引：54

作者：

Ohno, Osamu ^{[1
]}

Watabe, Taeko ^{[1
]}

Nakamura, Kazuhiko ^{[1
]}

Kawagoshi, Masaru ^{[2
]}

Uotsu, Nobuo ^{[2
]}

Chiba, Tomohiro ^{[2
]}

Yamada, Masayoshi ^{[2
]}

Yamaguchi, Kohji ^{[2
]}

Yamada, Kaoru ^{[1
]}

Miyamoto, Kenji ^{[1
]}

Uemura, Daisuke ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Yokohama, Kanagawa 2238522, Japan

[2] FANCL Corp, FANCL Res Inst, Yokohama, Kanagawa 2440806, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2010年 / 74卷 / 07期

关键词：

melanin; Piper longum; bakuchiol; bavachin; isobavachalcone; PSORALEA-CORYLIFOLIA; MELANOGENESIS; DERIVATIVES; CULTURE; SEEDS;

D O I：

10.1271/bbb.100221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

引用

页码：1504 / 1506

页数：3

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