Biomedical applications of amino acid-modified chitosans: A review

被引：114

作者：

Casettari, Luca ^{[1
]}

Vllasaliu, Driton ^{[2
]}

Lam, Jenny K. W. ^{[3
]}

Soliman, Mahrrioud ^{[4
]}

Illum, Lisbeth ^{[5
]}

机构：

[1] Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, Italy

[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

[3] Univ Hong Kong, LKS Fac Med, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China

[4] Ain Shams Univ, Fac Pharm, Cairo 11566, Egypt

[5] IDentity, Nottingham NG7 1BA, England

来源：

BIOMATERIALS | 2012年 / 33卷 / 30期

关键词：

Chitosan; Amino acid; Drug delivery; Gene therapy; Tissue engineering; IN-VITRO EVALUATION; SELF-ASSEMBLED NANOPARTICLES; EFFICIENT GENE-TRANSFER; ARGININE-RICH PEPTIDES; MUCOADHESIVE POLYMERS; POLY(GAMMA-GLUTAMIC ACID); TRANSFECTION EFFICIENCY; DRUG-DELIVERY; ABSORPTION ENHANCEMENT; DNA NANOPARTICLES;

D O I：

10.1016/j.biomaterials.2012.06.104

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The presence of reactive primary amines in the backbone structure of chitosan, enables the derivatisation with different functional groups and thereby improving and expanding its properties, such as solubility and mucoadhesiveness, for biomedical applications. Such derivatives can be exploited with good results in a number of biomedical areas, including enhancement of nucleic acid transfection in gene therapy, as well as many other applications aiming to maximize drug delivery and aiding tissue engineering. The aim of this review is to provide an up to date overview of the methods used for derivatizing the chitosan with amino acids and to discuss the characteristics and potential biomedical application of the different amino acid derivatized chitosans described in the literature. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7565 / 7583

页数：19

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