Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara

被引：74

作者：

Jiao, Wei-Hua ^{[1
]}

Huang, Xiao-Jun ^{[2
]}

Yang, Ji-Si ^{[1
]}

Yang, Fan ^{[1
]}

Piao, Shu-Jian ^{[1
]}

Gao, Hao ^{[2
]}

Li, Jia ^{[3
]}

Ye, Wen-Cai ^{[2
]}

Yao, Xin-Sheng ^{[2
]}

Chen, Wan-Sheng ^{[1
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

EFFICIENT TOTAL-SYNTHESIS; NATURAL-PRODUCTS; CONFIGURATION; HYDROQUINONE; METABOLITES;

D O I：

10.1021/ol202994c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dysidavarones A-D (1-4), four new sesquiterpene quinones possessing the unprecedented "dysidavarane" carbon skeleton, were isolated from the South China Sea sponge Dysidea avara. The structures were established by spectroscopic methods, and the absolute configurations were determined using quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum and exciton chirality CD method. Their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were also evaluated.

引用

页码：202 / 205

页数：4

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