A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease

被引:97
作者
Bhutani, Harpreet [1 ]
Smith, Vikram [1 ]
Rahbari-Oskoui, Frederic [1 ]
Mittal, Ankush [1 ]
Grantham, Jared J. [2 ]
Torres, Vicente E. [3 ]
Mrug, Michal [4 ]
Bae, Kyongtae T. [5 ]
Wu, Zhiyuan [5 ]
Ge, Yinghui [5 ]
Landslittel, Doug [5 ]
Gibbs, Patrice [5 ]
O'Neill, W. Charles [1 ]
Chapman, Arlene B. [1 ]
机构
[1] Emory Univ, Atlanta, GA 30322 USA
[2] Univ Kansas, Lawrence, KS 66045 USA
[3] Mayo Clin, Rochester, MN USA
[4] Univ Alabama Birmingham, Birmingham, AL USA
[5] Univ Pittsburgh, Pittsburgh, PA USA
关键词
magnetic resonance imaging; total kidney volume; ultrasound; RENAL-FUNCTION; VOLUME; PROGRESSION; CHILDREN; CONSORTIUM; CRISP;
D O I
10.1038/ki.2015.71
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Autosomal dominant polycystic kidney disease (ADPKD) is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 cc/m predicts the development of CKD stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine whether ultrasound and kidney length (KL) predict future CKD stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15-46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance, and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intraclass correlations. Each measure was tested to predict future CKD stage 3. Relatively strong intraclass correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD stage 3 similarly (AUC of 0.87, 0.88, 0.87, and 0.88, respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/min had the best cut point for predicting the development of CKD stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging.
引用
收藏
页码:146 / 151
页数:6
相关论文
共 20 条
[1]   Novel Approach to Estimate Kidney and Cyst Volumes Using Mid-Slice Magnetic Resonance Images in Polycystic Kidney Disease [J].
Bae, Kyongtae T. ;
Tao, Cheng ;
Wang, Jinhong ;
Kaya, Diana ;
Wu, Zhiyuan ;
Bae, Junu T. ;
Chapman, Arlene B. ;
Torres, Vicente E. ;
Grantham, Jared J. ;
Mrug, Michal ;
Bennett, William M. ;
Flessner, Michael F. ;
Landsittel, Doug P. .
AMERICAN JOURNAL OF NEPHROLOGY, 2013, 38 (04) :333-341
[2]   Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort [J].
Chapman, AB ;
Guay-Woodford, LM ;
Grantham, JJ ;
Torres, VE ;
Bae, KT ;
Baumgarten, DA ;
Kenney, PJ ;
King, BF ;
Glockner, JF ;
Wetzel, LH ;
Brummer, ME ;
O'Neill, WC ;
Robbin, ML ;
Bennett, WM ;
Klahr, S ;
Hirschman, GH ;
Kimmel, PL ;
Thompson, PA ;
Miller, JP .
KIDNEY INTERNATIONAL, 2003, 64 (03) :1035-1045
[3]  
CHAPMAN AB, 1994, J AM SOC NEPHROL, V5, P1349
[4]  
CHAPMAN AB, 1991, SEMIN NEPHROL, V11, P653
[5]   Kidney Volume and Functional Outcomes in Autosomal Dominant Polycystic Kidney Disease [J].
Chapman, Arlene B. ;
Bost, James E. ;
Torres, Vicente E. ;
Guay-Woodford, Lisa ;
Bae, Kyongtae Ty ;
Landsittel, Douglas ;
Li, Jie ;
King, Bernard F. ;
Martin, Diego ;
Wetzel, Louis H. ;
Lockhart, Mark E. ;
Harris, Peter C. ;
Moxey-Mims, Marva ;
Flessner, Mike ;
Bennett, William M. ;
Grantham, Jared J. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (03) :479-486
[6]  
DALGAARD O Z, 1957, Acta Med Scand Suppl, V328, P1
[7]   Autosomal dominant polycystic kidney disease is associated with an increased prevalence of radiographic bronchiectasis [J].
Driscoll, James A. ;
Bhalla, Sanjeev ;
Liapis, Helen ;
Ibricevic, Aida ;
Brody, Steven L. .
CHEST, 2008, 133 (05) :1181-1188
[8]   Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: A longitudinal study [J].
Fick-Brosnahan, GM ;
Belz, MM ;
McFann, KK ;
Johnson, AM ;
Schrier, RW .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (06) :1127-1134
[9]   Progression of autosomal-dominant polycystic kidney disease in children [J].
Fick-Brosnahan, GM ;
Tran, ZV ;
Johnson, AM ;
Strain, JD ;
Gabow, PA .
KIDNEY INTERNATIONAL, 2001, 59 (05) :1654-1662
[10]   RATE OF FUNCTIONAL DETERIORATION IN POLYCYSTIC KIDNEY-DISEASE [J].
FRANZ, KA ;
REUBI, FC .
KIDNEY INTERNATIONAL, 1983, 23 (03) :526-529