Clinical Considerations for Vascularized Composite Allotransplantation of the Eye

被引：11

作者：

Davidson, Edward H. ^{[1
]}

Wang, Eric W. ^{[2
]}

Yu, Jenny Y. ^{[3
]}

Fernandez-Miranda, Juan C. ^{[4
]}

Wang, Dawn J. ^{[1
]}

Li, Yang ^{[1
,5
]}

Miller, Maxine ^{[1
]}

Sivak, Wesley N. ^{[1
]}

Bourne, Debra ^{[1
]}

Wang, Hongkun ^{[1
]}

Solari, Mario G. ^{[1
]}

Schuman, Joel S. ^{[3
]}

Washington, Kia M. ^{[1
,6
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Plast Surg, Pittsburgh, PA USA

[2] Univ Pittsburgh, Sch Med, Dept Otolaryngol, Pittsburgh, PA USA

[3] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Sch Med, Dept Neurosurg, Pittsburgh, PA 15261 USA

[5] Fourth Mil Med Univ, Xijing Hosp, Dept Plast & Reconstruct Surg, Xian, Peoples R China

[6] Pittsburgh VA Healthcare Syst, Pittsburgh, PA USA

来源：

JOURNAL OF CRANIOFACIAL SURGERY | 2016年 / 27卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Composite tissue allotransplantation; eye transplant; face transplant; reconstructive transplantation; vascularized composite allotransplantation; RETINAL GANGLION-CELLS; MESENCHYMAL STEM-CELLS; CILIARY NEUROTROPHIC FACTOR; PERFUSED MAMMALIAN EYE; FACE TRANSPLANTATION; VISUAL-CORTEX; SWINE MODEL; TOLERANCE; ALLOGRAFTS; SURVIVAL;

D O I：

10.1097/SCS.0000000000002985

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration and their shortcomings as well as recent research and events that have brought eye transplantation closer to a potential clinical reality. In this article, we outline some potential considerations in patient selection, donor facial tissue procurement, eye tissue implantation, surgical procedure, and potential for functional outcomes.

引用

页码：1622 / 1628

页数：7

共 67 条

[1] A Comparison Between the Fluocinolone Acetonide (Retisert) and Dexamethasone (Ozurdex) Intravitreal Implants in Uveitis [J].

Arcinue, Cheryl A. ;

Ceron, Olga M. ;

Foster, C. Stephen .

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2013, 29 (05) :501-507

[2] A pilot study in sub-SMAS face transplantation: Defining donor compatibility and assessing outcomes in a cadaver model [J].

Baccarani, Alessio ;

Follmar, Keith E. ;

Das, Rajesh R. ;

Mukundan, Srinivasan ;

Marcus, Jeffrey R. ;

Levin, L. Scott ;

Erdmann, Detlev .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2007, 119 (01) :121-129

[3] An Anatomical Study of External Carotid Artery Vascular Territories in Face and Midface Flaps for Transplantation [J].

Banks, Nia D. ;

Hui-Chou, Helen G. ;

Tripathi, Satyen ;

Collins, Brendan J. ;

Stanwix, Matthew G. ;

Nam, Arthur J. ;

Rodriguez, Eduardo D. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2009, 123 (06) :1677-1687

[4] TOTAL EYE TRANSPLANTATION FOR THE BLIND - A CHALLENGE FOR THE FUTURE [J].

CANAVERO, S .

MEDICAL HYPOTHESES, 1992, 39 (03) :201-211

[5]

CARMIGNOTO G, 1989, J NEUROSCI, V9, P1263

[6] A Position Paper in Support of Face Transplantation in the Blind [J].

Carty, Matthew J. ;

Bueno, Ericka M. ;

Lehmann, Lisa S. ;

Pomahac, Bohdan .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2012, 130 (02) :319-324

[7] Oligodendrocyte precursor cells: Reactive cells that inhibit axon growth and regeneration [J].

Chen, ZJ ;

Negra, M ;

Levine, A ;

Ughrin, Y ;

Levine, JM .

JOURNAL OF NEUROCYTOLOGY, 2002, 31 (6-7) :481-495

[8] Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors [J].

de Lima, Silmara ;

Koriyama, Yoshiki ;

Kurimoto, Takuji ;

Oliveira, Julia Teixeira ;

Yin, Yuqin ;

Li, Yiqing ;

Gilbert, Hui-Ya ;

Fagiolini, Michela ;

Blanco Martinez, Ana Maria ;

Benowitz, Larry .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (23) :9149-9154

[9] Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation [J].

Ellenberg, D. ;

Shi, J. ;

Jain, S. ;

Chang, J-H ;

Ripps, H. ;

Brady, S. ;

Melhem, E. R. ;

Lakkis, F. ;

Adamis, A. ;

Chen, D-F ;

Ellis-Behnke, R. ;

Langer, R. S. ;

Strittmatter, S. M. ;

Azar, D. T. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2009, 93 (09) :1134-1140

[10] The Cleveland Clinic FACES Score: A Preliminary Assessment Tool for Identifying the Optimal Face Transplant Candidate [J].

Gordon, Chad R. ;

Siemionow, Maria ;

Coffman, Kathy ;

Alam, Daniel ;

Eghtesad, Bijan ;

Zins, James E. ;

Bernard, Steven ;

Fung, John ;

Pryor, Landon ;

Papay, Francis .

JOURNAL OF CRANIOFACIAL SURGERY, 2009, 20 (06) :1969-1974

← 1 2 3 4 5 6 7 →